Plasma SUMO1 Protein is Elevated in Alzheimer's Disease

Sun Jung Cho, Sang Moon Yun, Dae Hoon Lee, Chulman Jo, Moon Ho Park, Changsu Han, Young Ho Koh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common type of dementia in the elderly.Tthe accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD.Tthere is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse.Tthe present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y), and 133 cognitively normal controls (average age 71.97 y).Tthe plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups.Tthe levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =0.123, p = 0.029).Tthese results suggest that elevated plasma SUMO1 levels may be associated with AD.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalJournal of Alzheimer's Disease
Volume47
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Blood Proteins
Alzheimer Disease
Dementia
Amyloidogenic Proteins
tau Proteins
Brain Diseases
Ubiquitin
Amyloid
Enzyme-Linked Immunosorbent Assay
Control Groups
Peptides
Proteins

Keywords

  • Alzheimer's disease
  • biomarker
  • plasma
  • SUMO1

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Plasma SUMO1 Protein is Elevated in Alzheimer's Disease. / Cho, Sun Jung; Yun, Sang Moon; Lee, Dae Hoon; Jo, Chulman; Park, Moon Ho; Han, Changsu; Koh, Young Ho.

In: Journal of Alzheimer's Disease, Vol. 47, No. 3, 01.01.2015, p. 639-643.

Research output: Contribution to journalArticle

Cho, Sun Jung ; Yun, Sang Moon ; Lee, Dae Hoon ; Jo, Chulman ; Park, Moon Ho ; Han, Changsu ; Koh, Young Ho. / Plasma SUMO1 Protein is Elevated in Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2015 ; Vol. 47, No. 3. pp. 639-643.
@article{941950162f934771a3cefb45b6a2459b,
title = "Plasma SUMO1 Protein is Elevated in Alzheimer's Disease",
abstract = "Alzheimer's disease (AD) is the most common type of dementia in the elderly.Tthe accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD.Tthere is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse.Tthe present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y), and 133 cognitively normal controls (average age 71.97 y).Tthe plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups.Tthe levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =0.123, p = 0.029).Tthese results suggest that elevated plasma SUMO1 levels may be associated with AD.",
keywords = "Alzheimer's disease, biomarker, plasma, SUMO1",
author = "Cho, {Sun Jung} and Yun, {Sang Moon} and Lee, {Dae Hoon} and Chulman Jo and Park, {Moon Ho} and Changsu Han and Koh, {Young Ho}",
year = "2015",
month = "1",
day = "1",
doi = "10.3233/JAD-150103",
language = "English",
volume = "47",
pages = "639--643",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - Plasma SUMO1 Protein is Elevated in Alzheimer's Disease

AU - Cho, Sun Jung

AU - Yun, Sang Moon

AU - Lee, Dae Hoon

AU - Jo, Chulman

AU - Park, Moon Ho

AU - Han, Changsu

AU - Koh, Young Ho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Alzheimer's disease (AD) is the most common type of dementia in the elderly.Tthe accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD.Tthere is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse.Tthe present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y), and 133 cognitively normal controls (average age 71.97 y).Tthe plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups.Tthe levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =0.123, p = 0.029).Tthese results suggest that elevated plasma SUMO1 levels may be associated with AD.

AB - Alzheimer's disease (AD) is the most common type of dementia in the elderly.Tthe accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD.Tthere is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse.Tthe present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y), and 133 cognitively normal controls (average age 71.97 y).Tthe plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups.Tthe levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =0.123, p = 0.029).Tthese results suggest that elevated plasma SUMO1 levels may be associated with AD.

KW - Alzheimer's disease

KW - biomarker

KW - plasma

KW - SUMO1

UR - http://www.scopus.com/inward/record.url?scp=84938687615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938687615&partnerID=8YFLogxK

U2 - 10.3233/JAD-150103

DO - 10.3233/JAD-150103

M3 - Article

C2 - 26401699

AN - SCOPUS:84938687615

VL - 47

SP - 639

EP - 643

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 3

ER -