Plasma SUMO1 Protein is Elevated in Alzheimer's Disease

Sun Jung Cho, Sang Moon Yun, Dae Hoon Lee, Chulman Jo, Moon Ho Park, Changsu Han, Young Ho Koh

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Alzheimer's disease (AD) is the most common type of dementia in the elderly.Tthe accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD.Tthere is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse.Tthe present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y), and 133 cognitively normal controls (average age 71.97 y).Tthe plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups.Tthe levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =0.123, p = 0.029).Tthese results suggest that elevated plasma SUMO1 levels may be associated with AD.

    Original languageEnglish
    Pages (from-to)639-643
    Number of pages5
    JournalJournal of Alzheimer's Disease
    Volume47
    Issue number3
    DOIs
    Publication statusPublished - 2015 Aug 3

    Keywords

    • Alzheimer's disease
    • SUMO1
    • biomarker
    • plasma

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Clinical Psychology
    • Geriatrics and Gerontology
    • Psychiatry and Mental health

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