Abstract
The aim of this study was to explore whether the plasminogen activator inhibitor-1 (PAI-1) 4G/5G and the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms are associated with susceptibility to polycystic ovary syndrome (PCOS). Meta-analyses were conducted to determine the association between the PAI-1 4G/5G and MTHFR 677C/T polymorphisms and PCOS using: (1) allele contrast (2) homozygote contrast, (3) recessive, and (4) dominant models. For meta-analysis, nine studies of the PAI-1 4G/5G polymorphism with 2384 subjects (PCOS, 1615; controls, 769) and eight studies of the MTHFR 677C/T polymorphism with 1270 study subjects were included. Meta-analysis of all study subjects showed no association between PCOS and the PAI-1 4G allele (OR = 0.949, 95% CI = 0.671-1.343, p = 0.767). Stratification by ethnicity, however, indicated a significant association between the PAI-1 4G allele and PCOS in Turkish and Asian populations (OR = 0.776, 95% CI = 0.602-0.999, p = 0.049; OR = 1.749, 95% CI = 1.297-2.359, p = 2.5 × 10-5 respectively). In addition, meta-analysis indicated an association between PCOS and the PAI-1 4G4G + 4G5G genotype in Europeans (OR = 1.406, 95% CI = 1.025-1.928, p = 0.035). However, meta-analysis of all study subjects showed no association between PCOS and the MTHFR 677T allele (OR = 0.998, 95% CI = 0.762-1.307, p = 0.989), including Europeans (OR = 0.806, 95% CI = 0.610-1.063, p = 0.126). Meta-analysis showed no association between PCOS and the MTHFR 677C/T polymorphism using homozygote contrast, and recessive and dominant models. In conclusion, meta-analysis suggests the PAI-1 4G/5G polymorphism is associated with susceptibility to PCOS in European, Turkish, and Asian populations, but the MTHFR 677C/T polymorphism is not associated with susceptibility to PCOS in Europeans.
| Original language | English |
|---|---|
| Pages (from-to) | 8-14 |
| Number of pages | 7 |
| Journal | European Journal of Obstetrics Gynecology and Reproductive Biology |
| Volume | 175 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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Keywords
- Meta-analysis
- MTHFR
- PAI-1
- PCOS
- Polymorphism
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
Cite this
Plasminogen activator inhibitor-1 4G/5G and the MTHFR 677C/T polymorphisms and susceptibility to polycystic ovary syndrome : A meta-analysis. / Lee, Young Ho; Song, Gwan Gyu.
In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 175, No. 1, 01.01.2014, p. 8-14.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Plasminogen activator inhibitor-1 4G/5G and the MTHFR 677C/T polymorphisms and susceptibility to polycystic ovary syndrome
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Song, Gwan Gyu
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The aim of this study was to explore whether the plasminogen activator inhibitor-1 (PAI-1) 4G/5G and the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms are associated with susceptibility to polycystic ovary syndrome (PCOS). Meta-analyses were conducted to determine the association between the PAI-1 4G/5G and MTHFR 677C/T polymorphisms and PCOS using: (1) allele contrast (2) homozygote contrast, (3) recessive, and (4) dominant models. For meta-analysis, nine studies of the PAI-1 4G/5G polymorphism with 2384 subjects (PCOS, 1615; controls, 769) and eight studies of the MTHFR 677C/T polymorphism with 1270 study subjects were included. Meta-analysis of all study subjects showed no association between PCOS and the PAI-1 4G allele (OR = 0.949, 95% CI = 0.671-1.343, p = 0.767). Stratification by ethnicity, however, indicated a significant association between the PAI-1 4G allele and PCOS in Turkish and Asian populations (OR = 0.776, 95% CI = 0.602-0.999, p = 0.049; OR = 1.749, 95% CI = 1.297-2.359, p = 2.5 × 10-5 respectively). In addition, meta-analysis indicated an association between PCOS and the PAI-1 4G4G + 4G5G genotype in Europeans (OR = 1.406, 95% CI = 1.025-1.928, p = 0.035). However, meta-analysis of all study subjects showed no association between PCOS and the MTHFR 677T allele (OR = 0.998, 95% CI = 0.762-1.307, p = 0.989), including Europeans (OR = 0.806, 95% CI = 0.610-1.063, p = 0.126). Meta-analysis showed no association between PCOS and the MTHFR 677C/T polymorphism using homozygote contrast, and recessive and dominant models. In conclusion, meta-analysis suggests the PAI-1 4G/5G polymorphism is associated with susceptibility to PCOS in European, Turkish, and Asian populations, but the MTHFR 677C/T polymorphism is not associated with susceptibility to PCOS in Europeans.
AB - The aim of this study was to explore whether the plasminogen activator inhibitor-1 (PAI-1) 4G/5G and the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms are associated with susceptibility to polycystic ovary syndrome (PCOS). Meta-analyses were conducted to determine the association between the PAI-1 4G/5G and MTHFR 677C/T polymorphisms and PCOS using: (1) allele contrast (2) homozygote contrast, (3) recessive, and (4) dominant models. For meta-analysis, nine studies of the PAI-1 4G/5G polymorphism with 2384 subjects (PCOS, 1615; controls, 769) and eight studies of the MTHFR 677C/T polymorphism with 1270 study subjects were included. Meta-analysis of all study subjects showed no association between PCOS and the PAI-1 4G allele (OR = 0.949, 95% CI = 0.671-1.343, p = 0.767). Stratification by ethnicity, however, indicated a significant association between the PAI-1 4G allele and PCOS in Turkish and Asian populations (OR = 0.776, 95% CI = 0.602-0.999, p = 0.049; OR = 1.749, 95% CI = 1.297-2.359, p = 2.5 × 10-5 respectively). In addition, meta-analysis indicated an association between PCOS and the PAI-1 4G4G + 4G5G genotype in Europeans (OR = 1.406, 95% CI = 1.025-1.928, p = 0.035). However, meta-analysis of all study subjects showed no association between PCOS and the MTHFR 677T allele (OR = 0.998, 95% CI = 0.762-1.307, p = 0.989), including Europeans (OR = 0.806, 95% CI = 0.610-1.063, p = 0.126). Meta-analysis showed no association between PCOS and the MTHFR 677C/T polymorphism using homozygote contrast, and recessive and dominant models. In conclusion, meta-analysis suggests the PAI-1 4G/5G polymorphism is associated with susceptibility to PCOS in European, Turkish, and Asian populations, but the MTHFR 677C/T polymorphism is not associated with susceptibility to PCOS in Europeans.
KW - Meta-analysis
KW - MTHFR
KW - PAI-1
KW - PCOS
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84898059054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898059054&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2013.12.030
DO - 10.1016/j.ejogrb.2013.12.030
M3 - Review article
C2 - 24439532
AN - SCOPUS:84898059054
VL - 175
SP - 8
EP - 14
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
SN - 0028-2243
IS - 1
ER -