Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces

Hee Jung Lee, Ki Dong Park, Hyung Dal Park, Won Kyu Lee, Dong Keun Han, Soo Hyun Kim, Young Ha Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO3) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO3 chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.

Original languageEnglish
Pages (from-to)355-370
Number of pages16
JournalColloids and Surfaces B: Biointerfaces
Volume18
Issue number3-4
DOIs
Publication statusPublished - 2000 Oct

Keywords

  • Bacterial adhesion
  • Platelet adhesion
  • Sulfonated-PEG acrylate copolymers

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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