Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Nisar Ul Khaliq; Dal Yong Park; Byeong Min Yun; Da Hye Yang; Yong Woo Jung; Jae Hong Seo; Chang Soon Hwang; Soon Hong Yuk

doi:10.1016/j.ijpharm.2018.11.064

Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Nisar Ul Khaliq, Dal Yong Park, Byeong Min Yun, Da Hye Yang, Yong Woo Jung, Jae Hong Seo, Chang Soon Hwang, Soon Hong Yuk

Department of Biomedical Sciences

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

Original language	English
Pages (from-to)	30-44
Number of pages	15
Journal	International Journal of Pharmaceutics
Volume	556
DOIs	https://doi.org/10.1016/j.ijpharm.2018.11.064
Publication status	Published - 2019 Feb 10

Keywords

Doxorubicin
In situ gel
Macromolecules
Phase transition
Pluronic nanoparticles
Small molecules

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.ijpharm.2018.11.064

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Khaliq, N. U., Park, D. Y., Yun, B. M., Yang, D. H., Jung, Y. W., Seo, J. H., Hwang, C. S., & Yuk, S. H. (2019). Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging. International Journal of Pharmaceutics, 556, 30-44. https://doi.org/10.1016/j.ijpharm.2018.11.064

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abstract = "Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.",

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author = "Khaliq, {Nisar Ul} and Park, {Dal Yong} and Yun, {Byeong Min} and Yang, {Da Hye} and Jung, {Yong Woo} and Seo, {Jae Hong} and Hwang, {Chang Soon} and Yuk, {Soon Hong}",

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AU - Khaliq, Nisar Ul

AU - Park, Dal Yong

AU - Yun, Byeong Min

AU - Yang, Da Hye

AU - Jung, Yong Woo

AU - Seo, Jae Hong

AU - Hwang, Chang Soon

AU - Yuk, Soon Hong

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AB - Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

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KW - Phase transition

KW - Pluronic nanoparticles

KW - Small molecules

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