Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Nisar Ul Khaliq; Dal Yong Park; Byeong Min Yun; Da Hye Yang; Yong Woo Jung; Jae Hong Seo; Chang Soon Hwang; Soon Hong Yuk

doi:10.1016/j.ijpharm.2018.11.064

Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Nisar Ul Khaliq, Dal Yong Park, Byeong Min Yun, Da Hye Yang, Yong Woo Jung, Jae Hong Seo, Chang Soon Hwang, Soon Hong Yuk

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

Original language	English
Pages (from-to)	30-44
Number of pages	15
Journal	International Journal of Pharmaceutics
Volume	556
DOIs	https://doi.org/10.1016/j.ijpharm.2018.11.064
Publication status	Published - 2019 Feb 10

Keywords

Doxorubicin
In situ gel
Macromolecules
Phase transition
Pluronic nanoparticles
Small molecules

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1016/j.ijpharm.2018.11.064

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title = "Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging",

abstract = "Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.",

keywords = "Doxorubicin, In situ gel, Macromolecules, Phase transition, Pluronic nanoparticles, Small molecules",

author = "Khaliq, {Nisar Ul} and Park, {Dal Yong} and Yun, {Byeong Min} and Yang, {Da Hye} and Jung, {Yong Woo} and Seo, {Jae Hong} and Hwang, {Chang Soon} and Yuk, {Soon Hong}",

note = "Funding Information: This work was supported by the Technology Innovation Program ( 10077501 ) by the Ministry of Trade, Industry & Energy ( MOTIE ), the Technology Development Program ( S2561925 ) funded by the Ministry of SMEs and Startups ( MSS ), and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute ( KHIDI ) funded by the Ministry of Health & Welfare ( HI17C2320 ), Republic of Korea.",

year = "2019",

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doi = "10.1016/j.ijpharm.2018.11.064",

language = "English",

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T2 - Intelligent building units for targeted cancer therapy and molecular imaging

AU - Khaliq, Nisar Ul

AU - Park, Dal Yong

AU - Yun, Byeong Min

AU - Yang, Da Hye

AU - Jung, Yong Woo

AU - Seo, Jae Hong

AU - Hwang, Chang Soon

AU - Yuk, Soon Hong

N1 - Funding Information: This work was supported by the Technology Innovation Program ( 10077501 ) by the Ministry of Trade, Industry & Energy ( MOTIE ), the Technology Development Program ( S2561925 ) funded by the Ministry of SMEs and Startups ( MSS ), and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute ( KHIDI ) funded by the Ministry of Health & Welfare ( HI17C2320 ), Republic of Korea.

PY - 2019/2/10

Y1 - 2019/2/10

N2 - Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

AB - Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

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KW - In situ gel

KW - Macromolecules

KW - Phase transition

KW - Pluronic nanoparticles

KW - Small molecules

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Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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