Abstract
Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.
| Original language | English |
|---|---|
| Pages (from-to) | 30-44 |
| Number of pages | 15 |
| Journal | International Journal of Pharmaceutics |
| Volume | 556 |
| DOIs | |
| Publication status | Published - 2019 Feb 10 |
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Keywords
- Doxorubicin
- In situ gel
- Macromolecules
- Phase transition
- Pluronic nanoparticles
- Small molecules
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Pluronics : Intelligent building units for targeted cancer therapy and molecular imaging. / Khaliq, Nisar Ul; Park, Dal Yong; Yun, Byeong Min; Yang, Da Hye; Jung, Yong Woo; Seo, Jae Hong; Hwang, Chang Soon; Yuk, Soon Hong.
In: International Journal of Pharmaceutics, Vol. 556, 10.02.2019, p. 30-44.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pluronics
T2 - Intelligent building units for targeted cancer therapy and molecular imaging
AU - Khaliq, Nisar Ul
AU - Park, Dal Yong
AU - Yun, Byeong Min
AU - Yang, Da Hye
AU - Jung, Yong Woo
AU - Seo, Jae Hong
AU - Hwang, Chang Soon
AU - Yuk, Soon Hong
PY - 2019/2/10
Y1 - 2019/2/10
N2 - Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.
AB - Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.
KW - Doxorubicin
KW - In situ gel
KW - Macromolecules
KW - Phase transition
KW - Pluronic nanoparticles
KW - Small molecules
UR - http://www.scopus.com/inward/record.url?scp=85058220167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058220167&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2018.11.064
DO - 10.1016/j.ijpharm.2018.11.064
M3 - Article
C2 - 30529667
AN - SCOPUS:85058220167
VL - 556
SP - 30
EP - 44
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
ER -