pN3M0 gastric cancer: The category that allows the sub-classification of stage-IV gastric cancer (IVa and IVb)

Joong Min Park, Sungsoo Park, Young Jae Mok, Chong Suk Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Since the publication of the fifth edition of the UICC TNM classification, the rate of curative surgical resection for stage-IV gastric cancer has increased. It is related to the N3 category, which was the prior pN1 or pN2 in the fourth UICC TNM staging system and now pN3 in the fifth. We performed a retrospective analysis to determine whether the prognosis of N3M0 gastric cancer is different from that of other stage-IV gastric cancer; this may support sub-division of this disease. Methods: We analyzed 422 patients with stage-IV gastric cancer who underwent gastric resection from 1983 to 2002 at Korea University Hospital. Clinical and pathological characteristics as well as survival of the patients were evaluated retrospectively according to the TNM categories. Results: The 5-year survival rate for those with N3M0 gastric cancer was 10.5%; this was influenced by depth of invasion (P = 0.001). According to the survival analysis in patients with stage-IV subtypes, the mean survival time was 25.6 months for T1-3N3M0, 24.7 months for T4N1-2M0, 10.0 months for T4N3M0, and 13.6 months for anyT anyNM1. Thus, the survival of patients with T4N3M0 and M1 stage disease was significantly shorter than that of patients with T1-3N3M0 and T4N1-2M0 stage disease (P = 0.000). Conclusions: Sub-classification of stage-IV gastric cancer into IVa (T1-3N3M0, T4N1-2M0) and IVb (T4N3M0, anyT anyNM1) may be helpful to predict the outcome of patients with stage-IV gastric cancer.

Original languageEnglish
Pages (from-to)2535-2542
Number of pages8
JournalAnnals of Surgical Oncology
Volume14
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Stomach Neoplasms
Neoplasm Staging
Survival Rate
Survival
Survival Analysis
Korea
Publications
Stomach

Keywords

  • Gastric Cancer
  • N3
  • Stage-IV
  • Sub-Classification

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

pN3M0 gastric cancer : The category that allows the sub-classification of stage-IV gastric cancer (IVa and IVb). / Park, Joong Min; Park, Sungsoo; Mok, Young Jae; Kim, Chong Suk.

In: Annals of Surgical Oncology, Vol. 14, No. 9, 01.09.2007, p. 2535-2542.

Research output: Contribution to journalArticle

@article{66806019f2df46ca8c098802992db848,
title = "pN3M0 gastric cancer: The category that allows the sub-classification of stage-IV gastric cancer (IVa and IVb)",
abstract = "Background: Since the publication of the fifth edition of the UICC TNM classification, the rate of curative surgical resection for stage-IV gastric cancer has increased. It is related to the N3 category, which was the prior pN1 or pN2 in the fourth UICC TNM staging system and now pN3 in the fifth. We performed a retrospective analysis to determine whether the prognosis of N3M0 gastric cancer is different from that of other stage-IV gastric cancer; this may support sub-division of this disease. Methods: We analyzed 422 patients with stage-IV gastric cancer who underwent gastric resection from 1983 to 2002 at Korea University Hospital. Clinical and pathological characteristics as well as survival of the patients were evaluated retrospectively according to the TNM categories. Results: The 5-year survival rate for those with N3M0 gastric cancer was 10.5{\%}; this was influenced by depth of invasion (P = 0.001). According to the survival analysis in patients with stage-IV subtypes, the mean survival time was 25.6 months for T1-3N3M0, 24.7 months for T4N1-2M0, 10.0 months for T4N3M0, and 13.6 months for anyT anyNM1. Thus, the survival of patients with T4N3M0 and M1 stage disease was significantly shorter than that of patients with T1-3N3M0 and T4N1-2M0 stage disease (P = 0.000). Conclusions: Sub-classification of stage-IV gastric cancer into IVa (T1-3N3M0, T4N1-2M0) and IVb (T4N3M0, anyT anyNM1) may be helpful to predict the outcome of patients with stage-IV gastric cancer.",
keywords = "Gastric Cancer, N3, Stage-IV, Sub-Classification",
author = "Park, {Joong Min} and Sungsoo Park and Mok, {Young Jae} and Kim, {Chong Suk}",
year = "2007",
month = "9",
day = "1",
doi = "10.1245/s10434-007-9445-1",
language = "English",
volume = "14",
pages = "2535--2542",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - pN3M0 gastric cancer

T2 - The category that allows the sub-classification of stage-IV gastric cancer (IVa and IVb)

AU - Park, Joong Min

AU - Park, Sungsoo

AU - Mok, Young Jae

AU - Kim, Chong Suk

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Background: Since the publication of the fifth edition of the UICC TNM classification, the rate of curative surgical resection for stage-IV gastric cancer has increased. It is related to the N3 category, which was the prior pN1 or pN2 in the fourth UICC TNM staging system and now pN3 in the fifth. We performed a retrospective analysis to determine whether the prognosis of N3M0 gastric cancer is different from that of other stage-IV gastric cancer; this may support sub-division of this disease. Methods: We analyzed 422 patients with stage-IV gastric cancer who underwent gastric resection from 1983 to 2002 at Korea University Hospital. Clinical and pathological characteristics as well as survival of the patients were evaluated retrospectively according to the TNM categories. Results: The 5-year survival rate for those with N3M0 gastric cancer was 10.5%; this was influenced by depth of invasion (P = 0.001). According to the survival analysis in patients with stage-IV subtypes, the mean survival time was 25.6 months for T1-3N3M0, 24.7 months for T4N1-2M0, 10.0 months for T4N3M0, and 13.6 months for anyT anyNM1. Thus, the survival of patients with T4N3M0 and M1 stage disease was significantly shorter than that of patients with T1-3N3M0 and T4N1-2M0 stage disease (P = 0.000). Conclusions: Sub-classification of stage-IV gastric cancer into IVa (T1-3N3M0, T4N1-2M0) and IVb (T4N3M0, anyT anyNM1) may be helpful to predict the outcome of patients with stage-IV gastric cancer.

AB - Background: Since the publication of the fifth edition of the UICC TNM classification, the rate of curative surgical resection for stage-IV gastric cancer has increased. It is related to the N3 category, which was the prior pN1 or pN2 in the fourth UICC TNM staging system and now pN3 in the fifth. We performed a retrospective analysis to determine whether the prognosis of N3M0 gastric cancer is different from that of other stage-IV gastric cancer; this may support sub-division of this disease. Methods: We analyzed 422 patients with stage-IV gastric cancer who underwent gastric resection from 1983 to 2002 at Korea University Hospital. Clinical and pathological characteristics as well as survival of the patients were evaluated retrospectively according to the TNM categories. Results: The 5-year survival rate for those with N3M0 gastric cancer was 10.5%; this was influenced by depth of invasion (P = 0.001). According to the survival analysis in patients with stage-IV subtypes, the mean survival time was 25.6 months for T1-3N3M0, 24.7 months for T4N1-2M0, 10.0 months for T4N3M0, and 13.6 months for anyT anyNM1. Thus, the survival of patients with T4N3M0 and M1 stage disease was significantly shorter than that of patients with T1-3N3M0 and T4N1-2M0 stage disease (P = 0.000). Conclusions: Sub-classification of stage-IV gastric cancer into IVa (T1-3N3M0, T4N1-2M0) and IVb (T4N3M0, anyT anyNM1) may be helpful to predict the outcome of patients with stage-IV gastric cancer.

KW - Gastric Cancer

KW - N3

KW - Stage-IV

KW - Sub-Classification

UR - http://www.scopus.com/inward/record.url?scp=34548564516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548564516&partnerID=8YFLogxK

U2 - 10.1245/s10434-007-9445-1

DO - 10.1245/s10434-007-9445-1

M3 - Article

C2 - 17549571

AN - SCOPUS:34548564516

VL - 14

SP - 2535

EP - 2542

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 9

ER -