TY - JOUR
T1 - Poikiloderma vasculare atrophicans showing features of ashy dermatosis in the beginning
AU - Jeon, Jiehyun
AU - Kim, Joo Ha
AU - Ahn, Jae Woo
AU - Song, Hae Jun
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
AB - Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
KW - CD4
KW - CD4-CD8 ratio
KW - CD8
KW - Mycosis fungoides
KW - Poikiloderma
KW - T-lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=84925687331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925687331&partnerID=8YFLogxK
U2 - 10.5021/ad.2015.27.2.197
DO - 10.5021/ad.2015.27.2.197
M3 - Article
AN - SCOPUS:84925687331
VL - 27
SP - 197
EP - 200
JO - Annals of Dermatology
JF - Annals of Dermatology
SN - 1013-9087
IS - 2
ER -