Abstract
Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
| Original language | English |
|---|---|
| Pages (from-to) | 197-200 |
| Number of pages | 4 |
| Journal | Annals of Dermatology |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- CD4
- CD4-CD8 ratio
- CD8
- Mycosis fungoides
- Poikiloderma
- T-lymphocytes
ASJC Scopus subject areas
- Dermatology
Cite this
Poikiloderma vasculare atrophicans showing features of ashy dermatosis in the beginning. / Jeon, Jiehyun; Kim, Joo Ha; Ahn, Jae Woo; Song, Hae Jun.
In: Annals of Dermatology, Vol. 27, No. 2, 01.01.2015, p. 197-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Poikiloderma vasculare atrophicans showing features of ashy dermatosis in the beginning
AU - Jeon, Jiehyun
AU - Kim, Joo Ha
AU - Ahn, Jae Woo
AU - Song, Hae Jun
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
AB - Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
KW - CD4
KW - CD4-CD8 ratio
KW - CD8
KW - Mycosis fungoides
KW - Poikiloderma
KW - T-lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=84925687331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925687331&partnerID=8YFLogxK
U2 - 10.5021/ad.2015.27.2.197
DO - 10.5021/ad.2015.27.2.197
M3 - Article
AN - SCOPUS:84925687331
VL - 27
SP - 197
EP - 200
JO - Annals of Dermatology
JF - Annals of Dermatology
SN - 1013-9087
IS - 2
ER -