Polarization sensitive optical coherence tomography for monitoring wound healing process

Sang Won Lee, Jung Taek Oh, Yeon Su Kim, Beop-Min Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We use polarization sensitive optical coherence tomography (PS-OCT) to monitor wound healing processes in-vitro and in-vivo, which are affected by various drugs. Five rabbit subjects are used for the in-vitro studies and another five are used for in-vivo studies. The in-vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control), the second site is treated with sphingosyl phosphoryl choline (SPC), which is known to promote healing, and the last is administered with tetra acetyl phytosphingo sine (TAPS), which negatively affects the healing process. Each site is examined with a PS-OCT system and conventional histopathology at 1-, 4-, 7-, 10-, and 14-days after wound generation. The phase retardation values are quantified for all cases and our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration during the healing process; therefore, various drug effects can be noninvasively monitored.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages292-296
Number of pages5
Volume5690
DOIs
Publication statusPublished - 2005
Externally publishedYes
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: 2005 Jan 232005 Jan 26

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
CountryUnited States
CitySan Jose, CA
Period05/1/2305/1/26

Fingerprint

Optical tomography
Polarization
Monitoring
Biopsy
Collagen
Visualization
Fibers

Keywords

  • Collagen fiber
  • PS-OCT
  • SPC
  • TAPS
  • Wound healing

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lee, S. W., Oh, J. T., Kim, Y. S., & Kim, B-M. (2005). Polarization sensitive optical coherence tomography for monitoring wound healing process. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5690, pp. 292-296). [50] https://doi.org/10.1117/12.592511

Polarization sensitive optical coherence tomography for monitoring wound healing process. / Lee, Sang Won; Oh, Jung Taek; Kim, Yeon Su; Kim, Beop-Min.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 5690 2005. p. 292-296 50.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, SW, Oh, JT, Kim, YS & Kim, B-M 2005, Polarization sensitive optical coherence tomography for monitoring wound healing process. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5690, 50, pp. 292-296, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, San Jose, CA, United States, 05/1/23. https://doi.org/10.1117/12.592511
Lee SW, Oh JT, Kim YS, Kim B-M. Polarization sensitive optical coherence tomography for monitoring wound healing process. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5690. 2005. p. 292-296. 50 https://doi.org/10.1117/12.592511
Lee, Sang Won ; Oh, Jung Taek ; Kim, Yeon Su ; Kim, Beop-Min. / Polarization sensitive optical coherence tomography for monitoring wound healing process. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 5690 2005. pp. 292-296
@inproceedings{5c316fa512b64a5ea6dc43c9f4fd2f2e,
title = "Polarization sensitive optical coherence tomography for monitoring wound healing process",
abstract = "We use polarization sensitive optical coherence tomography (PS-OCT) to monitor wound healing processes in-vitro and in-vivo, which are affected by various drugs. Five rabbit subjects are used for the in-vitro studies and another five are used for in-vivo studies. The in-vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control), the second site is treated with sphingosyl phosphoryl choline (SPC), which is known to promote healing, and the last is administered with tetra acetyl phytosphingo sine (TAPS), which negatively affects the healing process. Each site is examined with a PS-OCT system and conventional histopathology at 1-, 4-, 7-, 10-, and 14-days after wound generation. The phase retardation values are quantified for all cases and our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration during the healing process; therefore, various drug effects can be noninvasively monitored.",
keywords = "Collagen fiber, PS-OCT, SPC, TAPS, Wound healing",
author = "Lee, {Sang Won} and Oh, {Jung Taek} and Kim, {Yeon Su} and Beop-Min Kim",
year = "2005",
doi = "10.1117/12.592511",
language = "English",
volume = "5690",
pages = "292--296",
editor = "V.V. Tuchin and J.A. Izatt and J.G. Fujimoto",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Polarization sensitive optical coherence tomography for monitoring wound healing process

AU - Lee, Sang Won

AU - Oh, Jung Taek

AU - Kim, Yeon Su

AU - Kim, Beop-Min

PY - 2005

Y1 - 2005

N2 - We use polarization sensitive optical coherence tomography (PS-OCT) to monitor wound healing processes in-vitro and in-vivo, which are affected by various drugs. Five rabbit subjects are used for the in-vitro studies and another five are used for in-vivo studies. The in-vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control), the second site is treated with sphingosyl phosphoryl choline (SPC), which is known to promote healing, and the last is administered with tetra acetyl phytosphingo sine (TAPS), which negatively affects the healing process. Each site is examined with a PS-OCT system and conventional histopathology at 1-, 4-, 7-, 10-, and 14-days after wound generation. The phase retardation values are quantified for all cases and our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration during the healing process; therefore, various drug effects can be noninvasively monitored.

AB - We use polarization sensitive optical coherence tomography (PS-OCT) to monitor wound healing processes in-vitro and in-vivo, which are affected by various drugs. Five rabbit subjects are used for the in-vitro studies and another five are used for in-vivo studies. The in-vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control), the second site is treated with sphingosyl phosphoryl choline (SPC), which is known to promote healing, and the last is administered with tetra acetyl phytosphingo sine (TAPS), which negatively affects the healing process. Each site is examined with a PS-OCT system and conventional histopathology at 1-, 4-, 7-, 10-, and 14-days after wound generation. The phase retardation values are quantified for all cases and our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration during the healing process; therefore, various drug effects can be noninvasively monitored.

KW - Collagen fiber

KW - PS-OCT

KW - SPC

KW - TAPS

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=21844463800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21844463800&partnerID=8YFLogxK

U2 - 10.1117/12.592511

DO - 10.1117/12.592511

M3 - Conference contribution

AN - SCOPUS:21844463800

VL - 5690

SP - 292

EP - 296

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

A2 - Tuchin, V.V.

A2 - Izatt, J.A.

A2 - Fujimoto, J.G.

ER -