Abstract
Poly–γ-glutamic acid (γ-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of γ-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that γ-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. γ-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of γ-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that γ-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.
Original language | English |
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Pages (from-to) | 80-86 |
Number of pages | 7 |
Journal | Immunology Letters |
Volume | 203 |
DOIs | |
Publication status | Published - 2018 Nov |
Keywords
- Osteoclast
- Poly-γ-glutamic acid (γ -PGA)
- Rheumatoid arthritis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology