Poly-γ-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis model

Bitnara Lee, Sungsin Jo, Sung Min Kim, Mi La Cho, Sung Hwan Park, Jeehee Youn, Jong Dae Ji, Tae Hwan Kim

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Poly–γ-glutamic acid (γ-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of γ-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that γ-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. γ-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of γ-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that γ-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.

    Original languageEnglish
    Pages (from-to)80-86
    Number of pages7
    JournalImmunology Letters
    Volume203
    DOIs
    Publication statusPublished - 2018 Nov

    Keywords

    • Osteoclast
    • Poly-γ-glutamic acid (γ -PGA)
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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