Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung Heon Lee, In San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman, Won Jong Kim

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

Original languageEnglish
Article number3702
JournalNature communications
Volume5
DOIs
Publication statusPublished - 2014 May 8
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Namgung, R., Mi Lee, Y., Kim, J., Jang, Y., Lee, B. H., Kim, I. S., Sokkar, P., Rhee, Y. M., Hoffman, A. S., & Kim, W. J. (2014). Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy. Nature communications, 5, [3702]. https://doi.org/10.1038/ncomms4702