Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Hyeonjeong Jeon; Jihoon Kim; Yeong Mi Lee; Jinhwan Kim; Hyung Woo Choi; Junseok Lee; Hyeongmok Park; Youngnam Kang; In San Kim; Byung Heon Lee; Allan S. Hoffman; Won Jong Kim

doi:10.1016/j.jconrel.2016.01.006

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Hyeonjeong Jeon, Jihoon Kim, Yeong Mi Lee, Jinhwan Kim, Hyung Woo Choi, Junseok Lee, Hyeongmok Park, Youngnam Kang, In San Kim, Byung Heon Lee, Allan S. Hoffman, Won Jong Kim

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

Original language	English
Pages (from-to)	68-76
Number of pages	9
Journal	Journal of Controlled Release
Volume	231
DOIs	https://doi.org/10.1016/j.jconrel.2016.01.006
Publication status	Published - 2016 Jun 10

Keywords

Cyclodextrin
Magnetic-guided drug delivery
Multivalent host-guest chemistry
Paclitaxel
SPION

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2016.01.006

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title = "Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system",

abstract = "This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.",

keywords = "Cyclodextrin, Magnetic-guided drug delivery, Multivalent host-guest chemistry, Paclitaxel, SPION",

author = "Hyeonjeong Jeon and Jihoon Kim and Lee, {Yeong Mi} and Jinhwan Kim and Choi, {Hyung Woo} and Junseok Lee and Hyeongmok Park and Youngnam Kang and Kim, {In San} and Lee, {Byung Heon} and Hoffman, {Allan S.} and Kim, {Won Jong}",

year = "2016",

month = jun,

day = "10",

doi = "10.1016/j.jconrel.2016.01.006",

language = "English",

volume = "231",

pages = "68--76",

journal = "Journal of Controlled Release",

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AU - Jeon, Hyeonjeong

AU - Kim, Jihoon

AU - Lee, Yeong Mi

AU - Kim, Jinhwan

AU - Choi, Hyung Woo

AU - Lee, Junseok

AU - Park, Hyeongmok

AU - Kang, Youngnam

AU - Kim, In San

AU - Lee, Byung Heon

AU - Hoffman, Allan S.

AU - Kim, Won Jong

PY - 2016/6/10

Y1 - 2016/6/10

N2 - This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

AB - This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

KW - Cyclodextrin

KW - Magnetic-guided drug delivery

KW - Multivalent host-guest chemistry

KW - Paclitaxel

KW - SPION

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M3 - Article

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SN - 0168-3659

VL - 231

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Abstract

Keywords

ASJC Scopus subject areas

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