Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Hyeonjeong Jeon, Jihoon Kim, Yeong Mi Lee, Jinhwan Kim, Hyung Woo Choi, Junseok Lee, Hyeongmok Park, Youngnam Kang, In-San Kim, Byung Heon Lee, Allan S. Hoffman, Won Jong Kim

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalJournal of Controlled Release
Volume231
DOIs
Publication statusPublished - 2016 Jun 10

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Keywords

  • Cyclodextrin
  • Magnetic-guided drug delivery
  • Multivalent host-guest chemistry
  • Paclitaxel
  • SPION

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Jeon, H., Kim, J., Lee, Y. M., Kim, J., Choi, H. W., Lee, J., Park, H., Kang, Y., Kim, I-S., Lee, B. H., Hoffman, A. S., & Kim, W. J. (2016). Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system. Journal of Controlled Release, 231, 68-76. https://doi.org/10.1016/j.jconrel.2016.01.006