Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Sae Rom Choi, Dong Jin Jang, Sanghyun Kim, Sunhyung An, Jinwoo Lee, Euichaul Oh, Jungbae Kim

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

Original languageEnglish
Pages (from-to)616-619
Number of pages4
JournalJournal of Materials Chemistry B
Volume2
Issue number6
DOIs
Publication statusPublished - 2014 Feb 14

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Fingerprint

Dive into the research topics of 'Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin'. Together they form a unique fingerprint.

Cite this