Polymeric nanomedicine for cancer therapy

Jae Hyung Park, Seulki Lee, Jong Ho Kim, Kyeongsoon Park, Kwang Meyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

382 Citations (Scopus)

Abstract

Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines.

Original languageEnglish
Pages (from-to)113-137
Number of pages25
JournalProgress in Polymer Science (Oxford)
Volume33
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Fingerprint

Medical nanotechnology
therapy
Polymers
cancer
polymers
drugs
Bearings (structural)
Chemical modification
Micelles
biocompatibility
nanotechnology
Biocompatibility
Nanotechnology
Pharmaceutical Preparations
maintenance
micelles
DNA
deoxyribonucleic acid
Ligands
Cells

Keywords

  • Angiogenesis
  • Cancer therapy
  • Drug carrier
  • Polymeric nanomedicine
  • Targeted delivery

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Polymeric nanomedicine for cancer therapy. / Park, Jae Hyung; Lee, Seulki; Kim, Jong Ho; Park, Kyeongsoon; Kim, Kwang Meyung; Kwon, Ick Chan.

In: Progress in Polymer Science (Oxford), Vol. 33, No. 1, 01.01.2008, p. 113-137.

Research output: Contribution to journalArticle

Park, Jae Hyung ; Lee, Seulki ; Kim, Jong Ho ; Park, Kyeongsoon ; Kim, Kwang Meyung ; Kwon, Ick Chan. / Polymeric nanomedicine for cancer therapy. In: Progress in Polymer Science (Oxford). 2008 ; Vol. 33, No. 1. pp. 113-137.
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