Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Seulki Lee, Ju Hee Ryu, Kyeongsoon Park, Aeju Lee, Seung Young Lee, In Chan Youn, Cheol Hee Ahn, Soon Man Yoon, Seung Jae Myung, Dae Hyuk Moon, Xiaoyuan Chen, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

Original languageEnglish
Pages (from-to)4412-4416
Number of pages5
JournalNano Letters
Volume9
Issue number12
DOIs
Publication statusPublished - 2009 Dec 9
Externally publishedYes

Fingerprint

Nanosensors
protease
Peptide Hydrolases
platforms
Matrix Metalloproteinases
Nanoparticles
Infrared radiation
nanoparticles
biomarkers
matrices
peptides
mice
enzymes
tumors
cancer
polymers
Biomarkers
Heterografts
Peptides
Tumors

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. / Lee, Seulki; Ryu, Ju Hee; Park, Kyeongsoon; Lee, Aeju; Lee, Seung Young; Youn, In Chan; Ahn, Cheol Hee; Yoon, Soon Man; Myung, Seung Jae; Moon, Dae Hyuk; Chen, Xiaoyuan; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwang Meyung.

In: Nano Letters, Vol. 9, No. 12, 09.12.2009, p. 4412-4416.

Research output: Contribution to journalArticle

Lee, S, Ryu, JH, Park, K, Lee, A, Lee, SY, Youn, IC, Ahn, CH, Yoon, SM, Myung, SJ, Moon, DH, Chen, X, Choi, K, Kwon, IC & Kim, KM 2009, 'Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo', Nano Letters, vol. 9, no. 12, pp. 4412-4416. https://doi.org/10.1021/nl902709m
Lee, Seulki ; Ryu, Ju Hee ; Park, Kyeongsoon ; Lee, Aeju ; Lee, Seung Young ; Youn, In Chan ; Ahn, Cheol Hee ; Yoon, Soon Man ; Myung, Seung Jae ; Moon, Dae Hyuk ; Chen, Xiaoyuan ; Choi, Kuiwon ; Kwon, Ick Chan ; Kim, Kwang Meyung. / Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. In: Nano Letters. 2009 ; Vol. 9, No. 12. pp. 4412-4416.
@article{c07729040c874f55839d75a29411d5b9,
title = "Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo",
abstract = "We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.",
author = "Seulki Lee and Ryu, {Ju Hee} and Kyeongsoon Park and Aeju Lee and Lee, {Seung Young} and Youn, {In Chan} and Ahn, {Cheol Hee} and Yoon, {Soon Man} and Myung, {Seung Jae} and Moon, {Dae Hyuk} and Xiaoyuan Chen and Kuiwon Choi and Kwon, {Ick Chan} and Kim, {Kwang Meyung}",
year = "2009",
month = "12",
day = "9",
doi = "10.1021/nl902709m",
language = "English",
volume = "9",
pages = "4412--4416",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

AU - Lee, Seulki

AU - Ryu, Ju Hee

AU - Park, Kyeongsoon

AU - Lee, Aeju

AU - Lee, Seung Young

AU - Youn, In Chan

AU - Ahn, Cheol Hee

AU - Yoon, Soon Man

AU - Myung, Seung Jae

AU - Moon, Dae Hyuk

AU - Chen, Xiaoyuan

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwang Meyung

PY - 2009/12/9

Y1 - 2009/12/9

N2 - We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

AB - We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

UR - http://www.scopus.com/inward/record.url?scp=71949091979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71949091979&partnerID=8YFLogxK

U2 - 10.1021/nl902709m

DO - 10.1021/nl902709m

M3 - Article

VL - 9

SP - 4412

EP - 4416

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 12

ER -