Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Seulki Lee, Ju Hee Ryu, Kyeongsoon Park, Aeju Lee, Seung Young Lee, In Chan Youn, Cheol Hee Ahn, Soon Man Yoon, Seung Jae Myung, Dae Hyuk Moon, Xiaoyuan Chen, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim

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119 Citations (Scopus)

Abstract

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

Original languageEnglish
Pages (from-to)4412-4416
Number of pages5
JournalNano Letters
Volume9
Issue number12
DOIs
Publication statusPublished - 2009 Dec 9
Externally publishedYes

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ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Lee, S., Ryu, J. H., Park, K., Lee, A., Lee, S. Y., Youn, I. C., Ahn, C. H., Yoon, S. M., Myung, S. J., Moon, D. H., Chen, X., Choi, K., Kwon, I. C., & Kim, K. M. (2009). Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. Nano Letters, 9(12), 4412-4416. https://doi.org/10.1021/nl902709m