Polymeric nanoparticles for protein kinase activity

Jong Ho Kim, Seulki Lee, Kwang Meyung Kim, Hyesung Jeon, Rang Woon Park, In-San Kim, Kuiwon Choi, Ick Chan Kwon

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

Original languageEnglish
Pages (from-to)1346-1348
Number of pages3
JournalChemical Communications
Issue number13
DOIs
Publication statusPublished - 2007 Mar 28
Externally publishedYes

Fingerprint

kemptide
Nanoparticles
Protein Kinases
Small Molecule Libraries
Proteins
Polyetherimides
Phosphorylation
Fluorescein-5-isothiocyanate
Drug Discovery
Screening
Phosphotransferases
Throughput
Ions
Substrates
tetramethylrhodamine isothiocyanate
fluorescein isothiocyanate-polyethylenimine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kim, J. H., Lee, S., Kim, K. M., Jeon, H., Park, R. W., Kim, I-S., ... Kwon, I. C. (2007). Polymeric nanoparticles for protein kinase activity. Chemical Communications, (13), 1346-1348. https://doi.org/10.1039/b612773h

Polymeric nanoparticles for protein kinase activity. / Kim, Jong Ho; Lee, Seulki; Kim, Kwang Meyung; Jeon, Hyesung; Park, Rang Woon; Kim, In-San; Choi, Kuiwon; Kwon, Ick Chan.

In: Chemical Communications, No. 13, 28.03.2007, p. 1346-1348.

Research output: Contribution to journalArticle

Kim, JH, Lee, S, Kim, KM, Jeon, H, Park, RW, Kim, I-S, Choi, K & Kwon, IC 2007, 'Polymeric nanoparticles for protein kinase activity', Chemical Communications, no. 13, pp. 1346-1348. https://doi.org/10.1039/b612773h
Kim, Jong Ho ; Lee, Seulki ; Kim, Kwang Meyung ; Jeon, Hyesung ; Park, Rang Woon ; Kim, In-San ; Choi, Kuiwon ; Kwon, Ick Chan. / Polymeric nanoparticles for protein kinase activity. In: Chemical Communications. 2007 ; No. 13. pp. 1346-1348.
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