Polymers for bioimaging

Jong Ho Kim, Kyeongsoon Park, Hae Yun Nam, Seulki Lee, Kwang Meyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Many imaging techniques, such as optical imaging, magnetic resonance imaging, nuclear imaging, and ultrasound have been successfully utilized in clinical applications for the past decades. However, there is an urgent need to design new bioimaging probes because imaging of specific molecular pathways in vivo, particularly those that play key roles in disease processes, is hampered by the poor sensitivity and specificity with current low molecular weight imaging compounds. Recently, interdisciplinary research at the interface of polymer chemistry and the bioimaging sciences has led to the generation of polymer-based bioimaging probes for the diagnosis and treatment of disease. A combination of imaging modality and several biocompatible and/or biodegradable synthetic and natural polymers such as multivalent, branched, graft, and block copolymers, polysaccharides and dendrimers, has produced bioimaging probes which have prolonged plasma half-lives, enhanced stability, reduced toxicity, and improved target specificity. Bioimaging facilitates the integration of complex biological phenomena into the rapid visualization process in molecular levels, and are extending the applications into therapy and high throughput drug screening. This review describes the current advances in polymers for bioimaging and highlights their potentials in clinical applications.

Original languageEnglish
Pages (from-to)1031-1053
Number of pages23
JournalProgress in Polymer Science (Oxford)
Volume32
Issue number8-9
DOIs
Publication statusPublished - 2007 Aug 1
Externally publishedYes

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Keywords

  • Bioimaging
  • Conjugation
  • Imaging probes
  • Polymer
  • Targeting

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Kim, J. H., Park, K., Nam, H. Y., Lee, S., Kim, K. M., & Kwon, I. C. (2007). Polymers for bioimaging. Progress in Polymer Science (Oxford), 32(8-9), 1031-1053. https://doi.org/10.1016/j.progpolymsci.2007.05.016