Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients

Gang Jee Ko, Young Sun Kang, Mi Hwa Lee, Hye Kyoung Song, Hyoung Kyu Kim, Dae-Ryong Cha

Research output: Contribution to journalArticle

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Abstract

Aim: Inhibition of aldosterone system is beneficial in diabetic nephropathy, and aldosterone synthesis is regulated at the gene-encoding aldosterone synthase (CYP11B2). Considering the role of aldosterone in diabetic nephropathy, genetic polymorphism of this gene may contribute to the development and progression of diabetic nephropathy. In this study, we investigated whether it is associated with diabetic nephropathy in type 2 diabetic patients. Methods: 197 type 2 diabetic patients and 71 healthy controls were enrolled. The study subjects were divided into four groups: healthy controls with normoalbuminuria (n = 71), normoalbuminuric diabetic group (n = 71), microalbuminuric diabetic group (n = 51) and overt proteinuria group (n = 51). Polymorphism of aldosterone synthase gene was determined using standard PCR technique. Results: Higher frequency of TT genotype and T allele in steroidogenic factor-1 (SF-1) binding site and wild type (WT) in intronic conversion (IC) in CYP11B2 was observed in diabetic patients than controls. However, there was no significant difference in SF-1 and IC genotype among diabetic patients according to the state of diabetic nephropathy. Subgroup analysis based on SF-1 polymorphism demonstrated that TT genotype is associated with higher systolic and diastolic blood pressure and higher plasma aldosterone level. In addition, WT in IC genotype showed a significantly higher urinary albumin excretion rate. Plasma aldosterone level was significantly related with systolic blood pressure. Conclusion: Our study suggests that aldosterone synthase gene polymorphism is not associated with progression of diabetic nephropathy, but it may contribute to the development of hypertension associated with increased aldosterone secretion in type 2 diabetic patients.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
JournalNephrology
Volume13
Issue number6
DOIs
Publication statusPublished - 2008 Sep 1

Fingerprint

Cytochrome P-450 CYP11B2
Diabetic Nephropathies
Aldosterone
Steroidogenic Factor 1
Hypertension
Genotype
Genes
Blood Pressure
Genetic Polymorphisms
Proteinuria
Albumins
Alleles
Binding Sites
Polymerase Chain Reaction
Control Groups

Keywords

  • Aldosterone
  • Aldosterone synthase
  • Diabetic nephropathy
  • Polymorphism
  • Type 2 diabetes

ASJC Scopus subject areas

  • Nephrology

Cite this

Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients. / Ko, Gang Jee; Kang, Young Sun; Lee, Mi Hwa; Song, Hye Kyoung; Kim, Hyoung Kyu; Cha, Dae-Ryong.

In: Nephrology, Vol. 13, No. 6, 01.09.2008, p. 492-499.

Research output: Contribution to journalArticle

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