Polymorphism of the CD14 gene in perennial allergic rhinitis

Hee Joon Kang, Yun M. Choi, Sungwon Chae, Jeong-Soo Woo, Soon Jae Hwang, Heung Man Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives: Allergic diseases have strong genetic backgrounds. Recently, a C-T polymorphism in the promoter region of CD14 has been associated with phenotypes of atopy in some populations. The aim of this study was to investigate the association of CD14/-159 polymorphism with total serum IgE levels and number of positive skin prick tests in Korean population with perennial allergic rhinitis. Study design: Prospective study. Methods: Deoxyribonucleic acid obtained from 164 children with perennial allergic rhinitis and 160 healthy controls were typed for the promoter polymorphism of CD14 gene at position -159 by restriction fragment length polymorphism analysis. Genotype frequencies, total serum IgE levels, and the number of positive skin tests for each genotype were compared. Results: There were no significant differences in the CD14/-159 genotype frequencies between the allergic rhinitis group and the control group. In the skin prick test-positive population, the CC homozygotes were associated with higher serum total IgE levels and greater number of positive skin tests compared with subjects with CT and TT alleles (P < 0.05). Conclusions: The results from the present study suggest that CD14/-159 polymorphism may play a role in the development of perennial allergic rhinitis in Korean children.

Original languageEnglish
Pages (from-to)2081-2085
Number of pages5
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume70
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1

Fingerprint

Rhinitis, Allergic, Perennial
Skin Tests
Immunoglobulin E
Genotype
Genes
Serum
Population
Gene Order
Homozygote
Genetic Promoter Regions
Restriction Fragment Length Polymorphisms
Alleles
Prospective Studies
Phenotype
Control Groups
DNA

Keywords

  • Allergic rhinitis
  • CD14/-159 polymorphism

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Polymorphism of the CD14 gene in perennial allergic rhinitis. / Kang, Hee Joon; Choi, Yun M.; Chae, Sungwon; Woo, Jeong-Soo; Hwang, Soon Jae; Lee, Heung Man.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 70, No. 12, 01.12.2006, p. 2081-2085.

Research output: Contribution to journalArticle

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