Polymorphism rs4263535 in GABRA1 intron 4 was related to deeper sedation by intravenous midazolam

Yoon Ji Choi, Shin Yuong Lee, Kyung Sook Yang, Ji Young Park, Seung Zhoo Yoon, Suk Min Yoon

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Objective To evaluate whether polymorphisms in the gamma-aminobutyric acid A receptor α1 subunit (GABRA1) gene influence sleep induction time, bispectral index score (BIS) during sleep induction and the total dose of midazolam required to reach a Ramsay Sedation Assessment Scale (RSAS) score of 4. Methods Patients scheduled for elective orthopaedic surgery were enrolled. All patients received initial doses of 0.02 mg/kg intravenous midazolam. If the RSAS score did not reach 4, an additional 1-mg dose of midazolam was administered. Results were compared among groups of patients with five single-nucleotide polymorphisms (SNPs) in GABRA1: rs4263535, rs980791, rs6556562, rs998754 and rs2279020. Results A total of 104 patients were evaluated. Polymorphism rs4263535 was associated with the lowest BIS during sedation induction. Multinomial logistic regression analysis demonstrated that polymorphism rs4263535 was significantly associated with the total dose of midazolam required for sedation induction. Conclusions Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam. Patients with the A/A rs4263535 genotype required a smaller dose of midazolam.

    Original languageEnglish
    Pages (from-to)686-698
    Number of pages13
    JournalJournal of International Medical Research
    Volume43
    Issue number5
    DOIs
    Publication statusPublished - 2015 Oct 22

    Keywords

    • Benzodiazepine
    • gamma-aminobutyric acid A receptor
    • genetic
    • polymorphism

    ASJC Scopus subject areas

    • Biochemistry
    • Biochemistry, medical
    • Cell Biology

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