Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer

Eung Bae Lee, Hyo Sung Jeon, Seung Soo Yoo, Yi Young Choi, Hyo Gyoung Kang, Sukki Cho, Sung Ick Cha, Jin Eun Choi, Tae In Park, Byung Heon Lee, Rang Woon Park, In-San Kim, Young Mo Kang, Chang Ho Kim, Sanghoon Jheon, Tae Hoon Jung, Jae Yong Park

Research output: Contribution to journalArticle

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Abstract

Purpose: This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). Methods: Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Results: Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P trend for OS and DFS = 7 × 10-5 and 1 × 10-4, respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95% confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95% CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95% CI = 2.03-8.29, P = 8 × 10-5; and aHR for DFS = 2.89, 95% CI = 1.64-5.11, P = 3 × 10-4, respectively]. Conclusion: Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.

Original languageEnglish
Pages (from-to)2608-2618
Number of pages11
JournalAnnals of Surgical Oncology
Volume17
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Apoptosis
Disease-Free Survival
Single Nucleotide Polymorphism
Survival
Genotype
Genes
Confidence Intervals
Mass Spectrometry
Multivariate Analysis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Lee, E. B., Jeon, H. S., Yoo, S. S., Choi, Y. Y., Kang, H. G., Cho, S., ... Park, J. Y. (2010). Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. Annals of Surgical Oncology, 17(10), 2608-2618. https://doi.org/10.1245/s10434-010-1082-4

Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. / Lee, Eung Bae; Jeon, Hyo Sung; Yoo, Seung Soo; Choi, Yi Young; Kang, Hyo Gyoung; Cho, Sukki; Cha, Sung Ick; Choi, Jin Eun; Park, Tae In; Lee, Byung Heon; Park, Rang Woon; Kim, In-San; Kang, Young Mo; Kim, Chang Ho; Jheon, Sanghoon; Jung, Tae Hoon; Park, Jae Yong.

In: Annals of Surgical Oncology, Vol. 17, No. 10, 01.10.2010, p. 2608-2618.

Research output: Contribution to journalArticle

Lee, EB, Jeon, HS, Yoo, SS, Choi, YY, Kang, HG, Cho, S, Cha, SI, Choi, JE, Park, TI, Lee, BH, Park, RW, Kim, I-S, Kang, YM, Kim, CH, Jheon, S, Jung, TH & Park, JY 2010, 'Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer', Annals of Surgical Oncology, vol. 17, no. 10, pp. 2608-2618. https://doi.org/10.1245/s10434-010-1082-4
Lee, Eung Bae ; Jeon, Hyo Sung ; Yoo, Seung Soo ; Choi, Yi Young ; Kang, Hyo Gyoung ; Cho, Sukki ; Cha, Sung Ick ; Choi, Jin Eun ; Park, Tae In ; Lee, Byung Heon ; Park, Rang Woon ; Kim, In-San ; Kang, Young Mo ; Kim, Chang Ho ; Jheon, Sanghoon ; Jung, Tae Hoon ; Park, Jae Yong. / Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer. In: Annals of Surgical Oncology. 2010 ; Vol. 17, No. 10. pp. 2608-2618.
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abstract = "Purpose: This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). Methods: Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Results: Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P trend for OS and DFS = 7 × 10-5 and 1 × 10-4, respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95{\%} confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95{\%} CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95{\%} CI = 2.03-8.29, P = 8 × 10-5; and aHR for DFS = 2.89, 95{\%} CI = 1.64-5.11, P = 3 × 10-4, respectively]. Conclusion: Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.",
author = "Lee, {Eung Bae} and Jeon, {Hyo Sung} and Yoo, {Seung Soo} and Choi, {Yi Young} and Kang, {Hyo Gyoung} and Sukki Cho and Cha, {Sung Ick} and Choi, {Jin Eun} and Park, {Tae In} and Lee, {Byung Heon} and Park, {Rang Woon} and In-San Kim and Kang, {Young Mo} and Kim, {Chang Ho} and Sanghoon Jheon and Jung, {Tae Hoon} and Park, {Jae Yong}",
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T1 - Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer

AU - Lee, Eung Bae

AU - Jeon, Hyo Sung

AU - Yoo, Seung Soo

AU - Choi, Yi Young

AU - Kang, Hyo Gyoung

AU - Cho, Sukki

AU - Cha, Sung Ick

AU - Choi, Jin Eun

AU - Park, Tae In

AU - Lee, Byung Heon

AU - Park, Rang Woon

AU - Kim, In-San

AU - Kang, Young Mo

AU - Kim, Chang Ho

AU - Jheon, Sanghoon

AU - Jung, Tae Hoon

AU - Park, Jae Yong

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Purpose: This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). Methods: Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Results: Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P trend for OS and DFS = 7 × 10-5 and 1 × 10-4, respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95% confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95% CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95% CI = 2.03-8.29, P = 8 × 10-5; and aHR for DFS = 2.89, 95% CI = 1.64-5.11, P = 3 × 10-4, respectively]. Conclusion: Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.

AB - Purpose: This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). Methods: Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Results: Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P trend for OS and DFS = 7 × 10-5 and 1 × 10-4, respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95% confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95% CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95% CI = 2.03-8.29, P = 8 × 10-5; and aHR for DFS = 2.89, 95% CI = 1.64-5.11, P = 3 × 10-4, respectively]. Conclusion: Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.

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