Polymorphisms in TGF-β1 gene and the risk of lung cancer

Hyo Gyoung Kang, Myung Hwa Chae, Jung Min Park, Eun Jin Kim, Jae Hyung Park, Sin Kam, Sung Ick Cha, Chang Ho Kim, Rang Woon Park, Sun Hee Park, Yong Lim Kim, In San Kim, Tae Hoon Jung, Jae Yong Park

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Background: Transforming growth factor-β1 (TGF-β1) functions as a suppressor of tumor initiation by inhibiting cellular proliferation or by promoting cellular differentiation or apoptosis in the early phase of cancer development. Variations in the DNA sequence in the TGF-β1 gene may lead to altered TGF-β1 production and/or activity, and so this can modulate an individual's susceptibility to lung cancer. To test this hypothesis, we investigated the association of the TGF-β1 -509C > T and 869T > C (L10P) polymorphisms and their haplotypes with the risk of lung cancer in a Korean population. Methods: The TGF-β1 genotypes were determined in 432 lung cancer patients and in 432 healthy control subjects who were frequency-matched for age and gender. The TGF-β1 haplotypes were predicted using a Bayesian algorithm in the Phase program. Results: Individuals with at least one -509T allele were at a significantly decreased risk of adenocarcinoma (AC) and small cell carcinoma (SM), as compared with carriers with the -509CC genotype [adjusted odds ratio (OR), 0.63; 95% confidence interval (CI), 0.42-0.96; P = 0.04; and adjusted OR, 0.45; 95% CI, 0.27-0.76; P = 0.002; respectively]. For the 869T > C polymorphism, the combined TC + CC genotype was associated with a significantly decreased risk of SM compared with the TT genotype (adjusted OR, 0.52; 95% CI, 0.31-0.88; P = 0.01). Consistent with the results of the genotyping analyses, the -509T/869C haplotype was associated with a significantly decreased risk of AC and SM as compared with the -509C/869T haplotype (adjusted OR, 0.75; 95% CI, 0.57-0.98; P = 0.04; and adjusted OR, 0.67; 95% CI, 0.47-0.96; P = 0.02; respectively). Conclusion: The TGF-β1 -509C > T and 869T > C polymorphisms and their haplotypes may contribute to genetic susceptibility to AC and SM of the lung.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalLung Cancer
Volume52
Issue number1
DOIs
Publication statusPublished - 2006 Apr
Externally publishedYes

Keywords

  • Genetic susceptibility
  • Lung cancer
  • Polymorphism
  • TGF-β1

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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