Polymorphisms of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of the study was to investigate a possible association between the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 and spondyloarthropathies (SpA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in 54 SpA patients, 84 healthy control subjects and 87 bronchial asthma patients as disease controls. There were no significant differences in the genotype and allele frequencies of the CTLA-4 exon 1, promoter and Fas promoter genes among SpA, asthma patients and controls. No significant differences were found in age at onset, sex, disease duration, history of enthesopathy, peripheral arthritis and uveitis, Schober test, chest expansion, white blood cell count, C-reactive protein and erythrocyte sedimentation rate among patients with SpA according to the CTLA-4 exon 1, CTLA-4 promoter and Fas promoter polymorphisms. We found no association between the polymorphisms of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 genes and SpA. However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA.

Original languageEnglish
Pages (from-to)420-422
Number of pages3
JournalClinical Rheumatology
Volume20
Issue number6
DOIs
Publication statusPublished - 2001 Dec 22

Fingerprint

Spondylarthropathies
Exons
Asthma
Genotype
Blood Sedimentation
Uveitis
Leukocyte Count
Age of Onset
Gene Frequency
Restriction Fragment Length Polymorphisms
C-Reactive Protein
Genes
Arthritis
Healthy Volunteers
Thorax
Polymerase Chain Reaction
DNA

Keywords

  • CTLA-4
  • Fas polymorphisms
  • Spondyloarthropathies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

@article{380ad2912fdb4d3db6051aa5d8336c62,
title = "Polymorphisms of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies",
abstract = "The aim of the study was to investigate a possible association between the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 and spondyloarthropathies (SpA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in 54 SpA patients, 84 healthy control subjects and 87 bronchial asthma patients as disease controls. There were no significant differences in the genotype and allele frequencies of the CTLA-4 exon 1, promoter and Fas promoter genes among SpA, asthma patients and controls. No significant differences were found in age at onset, sex, disease duration, history of enthesopathy, peripheral arthritis and uveitis, Schober test, chest expansion, white blood cell count, C-reactive protein and erythrocyte sedimentation rate among patients with SpA according to the CTLA-4 exon 1, CTLA-4 promoter and Fas promoter polymorphisms. We found no association between the polymorphisms of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 genes and SpA. However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA.",
keywords = "CTLA-4, Fas polymorphisms, Spondyloarthropathies",
author = "Lee, {Young Ho} and Ji, {Jong Dae} and Jeongwon Sohn and Song, {Gwan Gyu}",
year = "2001",
month = "12",
day = "22",
doi = "10.1007/s100670170007",
language = "English",
volume = "20",
pages = "420--422",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer London",
number = "6",

}

TY - JOUR

T1 - Polymorphisms of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies

AU - Lee, Young Ho

AU - Ji, Jong Dae

AU - Sohn, Jeongwon

AU - Song, Gwan Gyu

PY - 2001/12/22

Y1 - 2001/12/22

N2 - The aim of the study was to investigate a possible association between the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 and spondyloarthropathies (SpA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in 54 SpA patients, 84 healthy control subjects and 87 bronchial asthma patients as disease controls. There were no significant differences in the genotype and allele frequencies of the CTLA-4 exon 1, promoter and Fas promoter genes among SpA, asthma patients and controls. No significant differences were found in age at onset, sex, disease duration, history of enthesopathy, peripheral arthritis and uveitis, Schober test, chest expansion, white blood cell count, C-reactive protein and erythrocyte sedimentation rate among patients with SpA according to the CTLA-4 exon 1, CTLA-4 promoter and Fas promoter polymorphisms. We found no association between the polymorphisms of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 genes and SpA. However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA.

AB - The aim of the study was to investigate a possible association between the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 and spondyloarthropathies (SpA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in 54 SpA patients, 84 healthy control subjects and 87 bronchial asthma patients as disease controls. There were no significant differences in the genotype and allele frequencies of the CTLA-4 exon 1, promoter and Fas promoter genes among SpA, asthma patients and controls. No significant differences were found in age at onset, sex, disease duration, history of enthesopathy, peripheral arthritis and uveitis, Schober test, chest expansion, white blood cell count, C-reactive protein and erythrocyte sedimentation rate among patients with SpA according to the CTLA-4 exon 1, CTLA-4 promoter and Fas promoter polymorphisms. We found no association between the polymorphisms of the CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 genes and SpA. However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA.

KW - CTLA-4

KW - Fas polymorphisms

KW - Spondyloarthropathies

UR - http://www.scopus.com/inward/record.url?scp=0034747256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034747256&partnerID=8YFLogxK

U2 - 10.1007/s100670170007

DO - 10.1007/s100670170007

M3 - Article

C2 - 11771526

AN - SCOPUS:0034747256

VL - 20

SP - 420

EP - 422

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 6

ER -