Poly(oxyethylene sugaramide)s: Unprecedented multihydroxyl building blocks for tumor-homing nanoassembly

Keunsoo Jeong, Yong Deok Lee, Solji Park, Eunjung Lee, Chang Keun Lim, Kyung Eun Lee, Hyesung Jeon, Jungahn Kim, Ick Chan Kwon, Chong Rae Park, Sehoon Kim

Research output: Contribution to journalArticle

Abstract

Hydrogen bonding is a major intermolecular interaction for self-assembly occurring in nature. Here we report novel polymeric carbohydrates, i.e., poly(oxyethylene galactaramide)s (PEGAs), as biomimetic building blocks to construct hydrogen bond-mediated self-assembled nanoparticles that are useful for biomedical in vivo applications. PEGAs were conceptually designed as a biocompatible hybrid between polysaccharide and poly(ethylene glycol) (PEG) to attain multivalent hydrogen bonding as well as fully hydrophilic, non-ionic and antifouling characteristics. It was revealed that PEGAs are capable of homospecies hydrogen bonding in water and constructing multi-chain assembled nanoparticles whose structural integrity is highly stable with varying concentration, temperature and pH. Using near-infrared fluorescence imaging we demonstrate facile blood circulation and efficient tumor accumulation of the self-assembled PEGA nanoparticles that were intravenously injected into mice. These in vivo behaviors elucidate the combined merits of our design strategy, i.e., biocompatible chemical constitution capable of multivalent hydrogen bonding, antifouling properties, minimal cell interaction and mesoscopic colloidal self-assembly, as well as size-motivated tumor targeting.

Original languageEnglish
Pages (from-to)3437-3442
Number of pages6
JournalJournal of Materials Chemistry B
Volume1
Issue number28
DOIs
Publication statusPublished - 2013 Jul 28

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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    Jeong, K., Lee, Y. D., Park, S., Lee, E., Lim, C. K., Lee, K. E., Jeon, H., Kim, J., Chan Kwon, I., Park, C. R., & Kim, S. (2013). Poly(oxyethylene sugaramide)s: Unprecedented multihydroxyl building blocks for tumor-homing nanoassembly. Journal of Materials Chemistry B, 1(28), 3437-3442. https://doi.org/10.1039/c3tb20387e