Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway

Min Kyung Jung, Soogyeong Ha, Ju Ah Son, Ji Hye Song, Younkyung Houh, Eujin Cho, Ji Hoon Chun, Suk Ran Yoon, Yoolhee Yang, Sa Ik Bang, Minjung Kim, Hyun Jeong Park, Dae Ho Cho

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Propionibacterium acnes (P. acnes) is a wellknown acne-inducing factor which causes inflammatory skin lesions by enhancing cytokine production through toll-like receptor 2 (TLR2). Green tea extract catechin has been documented to possess anti-inflammatory effects. However, little is known about the mechanisms involved or any direct effect of green tea catechin on acne. The present study investigated the therapeutic effects and mechanism of polyphenon-60, also known as green tea catechin compound, on acne in vitro and in vivo. In a clinical study using topical polyphenon-60 treatment, acne patients showed symptomatic improvement with decrease in the number of comedos and pustules. To investigate the mechanism underlying the activity of polyphenon-60 in acne therapy, an in vitro study was performed. We found that polyphenon-60 reduced the levels of P. acnes-enhanced TLR2 and interleukin-8 (IL-8) in THP-1 cells, human monocyte cell line and human primary monocytes. Taken together, these data demonstrate that polyphenon-60 has a therapeutic effect on acne by suppressing inflammation, specifically by inhibiting TLR2 expression and IL-8 secretion via down-regulation of extracellular signal-regulated kinases 1/2 (ERK1/2) pathway and activator protein-1 (AP-1) pathway.

Original languageEnglish
Pages (from-to)655-663
Number of pages9
JournalArchives of Dermatological Research
Volume304
Issue number8
DOIs
Publication statusPublished - 2012 Oct 1
Externally publishedYes

Fingerprint

Toll-Like Receptor 2
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Acne Vulgaris
Therapeutic Uses
Interleukin-8
Catechin
Tea
Propionibacterium acnes
Monocytes
Transcription Factor AP-1
Anti-Inflammatory Agents
Down-Regulation
Cytokines
Inflammation
Cell Line
Skin
Therapeutics

Keywords

  • Acne therapy
  • Activator protein-1
  • Extracellular signal-regulated kinases 1/2
  • Interleukin-8
  • Polyphenon-60
  • Toll like receptor 2

ASJC Scopus subject areas

  • Dermatology

Cite this

Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway. / Jung, Min Kyung; Ha, Soogyeong; Son, Ju Ah; Song, Ji Hye; Houh, Younkyung; Cho, Eujin; Chun, Ji Hoon; Yoon, Suk Ran; Yang, Yoolhee; Bang, Sa Ik; Kim, Minjung; Park, Hyun Jeong; Cho, Dae Ho.

In: Archives of Dermatological Research, Vol. 304, No. 8, 01.10.2012, p. 655-663.

Research output: Contribution to journalArticle

Jung, MK, Ha, S, Son, JA, Song, JH, Houh, Y, Cho, E, Chun, JH, Yoon, SR, Yang, Y, Bang, SI, Kim, M, Park, HJ & Cho, DH 2012, 'Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway', Archives of Dermatological Research, vol. 304, no. 8, pp. 655-663. https://doi.org/10.1007/s00403-012-1249-x
Jung, Min Kyung ; Ha, Soogyeong ; Son, Ju Ah ; Song, Ji Hye ; Houh, Younkyung ; Cho, Eujin ; Chun, Ji Hoon ; Yoon, Suk Ran ; Yang, Yoolhee ; Bang, Sa Ik ; Kim, Minjung ; Park, Hyun Jeong ; Cho, Dae Ho. / Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway. In: Archives of Dermatological Research. 2012 ; Vol. 304, No. 8. pp. 655-663.
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AU - Yoon, Suk Ran

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