Pooled analysis of the CONFIRM registries

Impact of gender on procedure and angiographic outcomes in patients undergoing orbital atherectomy for peripheral artery disease

Michael S. Lee, Timothy Canan, Seung-Woon Rha, Jihad Mustapha, George L. Adams

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To compare the acute procedure and angiographic outcomes of peripheral artery disease (PAD) patients treated with orbital atherectomy stratified by gender. Methods: The CONFIRM I, II, and III registries are US multicenter, nonrandomized, all-comers registries of PAD patients who were treated with orbital atherectomy. All patients with gender specified in the registry database were included in the current analysis, which compared the final residual stenosis achieved after atherectomy and the rate of acute complications in female and male patients. The 3 registries included 3131 patients with 4761 lesions: 1261 women (mean age 73.2±10.7 years) with 1874 lesions and 1870 men (mean age 70.4±10.2) with 2887 lesions. Results: The women were older (p<0.001) and had a higher but nonsignificant prevalence of critical limb ischemia (p=0.075). After treatment, the final residual stenosis in women vs. men was 9%±11% vs. 11%±11%, respectively (p<0.001). Women had a higher rate of all types of dissection (13.3% vs. 9.9%, p<0.001). However, both genders had similar rates of flow-limiting dissections (1.6% vs. 1.4%, p=0.61), perforation, slow flow, vessel closure, spasm, embolism, and thrombus formation. Conclusion: The gender analysis of the CONFIRM registries revealed that there was successful lesion modification with orbital atherectomy in both men and women; however, women had a higher rate of dissection (all types). This difference is likely because of the older age and higher percentage of critical limb ischemia in women in this cohort. These results, however, suggest that additional studies should be completed to further understand the increased risks for women vs. men during endovascular procedures.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of Endovascular Therapy
Volume22
Issue number1
DOIs
Publication statusPublished - 2015 Feb 1

Fingerprint

Atherectomy
Peripheral Arterial Disease
Registries
Dissection
Pathologic Constriction
Ischemia
Extremities
Endovascular Procedures
Spasm
Embolism
Thrombosis
Databases

Keywords

  • Atherectomy
  • Calcification
  • Dissection
  • Female gender
  • Peripheral artery disease
  • Procedure-related complications
  • Stenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Pooled analysis of the CONFIRM registries : Impact of gender on procedure and angiographic outcomes in patients undergoing orbital atherectomy for peripheral artery disease. / Lee, Michael S.; Canan, Timothy; Rha, Seung-Woon; Mustapha, Jihad; Adams, George L.

In: Journal of Endovascular Therapy, Vol. 22, No. 1, 01.02.2015, p. 57-62.

Research output: Contribution to journalArticle

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abstract = "Purpose: To compare the acute procedure and angiographic outcomes of peripheral artery disease (PAD) patients treated with orbital atherectomy stratified by gender. Methods: The CONFIRM I, II, and III registries are US multicenter, nonrandomized, all-comers registries of PAD patients who were treated with orbital atherectomy. All patients with gender specified in the registry database were included in the current analysis, which compared the final residual stenosis achieved after atherectomy and the rate of acute complications in female and male patients. The 3 registries included 3131 patients with 4761 lesions: 1261 women (mean age 73.2±10.7 years) with 1874 lesions and 1870 men (mean age 70.4±10.2) with 2887 lesions. Results: The women were older (p<0.001) and had a higher but nonsignificant prevalence of critical limb ischemia (p=0.075). After treatment, the final residual stenosis in women vs. men was 9{\%}±11{\%} vs. 11{\%}±11{\%}, respectively (p<0.001). Women had a higher rate of all types of dissection (13.3{\%} vs. 9.9{\%}, p<0.001). However, both genders had similar rates of flow-limiting dissections (1.6{\%} vs. 1.4{\%}, p=0.61), perforation, slow flow, vessel closure, spasm, embolism, and thrombus formation. Conclusion: The gender analysis of the CONFIRM registries revealed that there was successful lesion modification with orbital atherectomy in both men and women; however, women had a higher rate of dissection (all types). This difference is likely because of the older age and higher percentage of critical limb ischemia in women in this cohort. These results, however, suggest that additional studies should be completed to further understand the increased risks for women vs. men during endovascular procedures.",
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