Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.

S. E. Kim, J. T. Cho, D. S. Lee, J. K. Chung, Sungeun Kim, M. C. Lee, J. S. Lee, C. S. Koh

Research output: Contribution to journalArticle

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Abstract

We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing in the urine. In Fanconi Syndrome the tubular reabsorption of DMSA may also be reduced, thus explaining the poor renal uptake in this patient. A 99mTc-MDP bone scan showed faint renal uptake and diffuse high uptake mainly in the spine, demonstrating that the metabolic bone disease associated with Fanconi Syndrome can be another mechanism for poor renal visualization on bone scan.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Korean Medical Science
Volume9
Issue number1
Publication statusPublished - 1994 Feb 1
Externally publishedYes

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Technetium Tc 99m Dimercaptosuccinic Acid
Fanconi Syndrome
Technetium
Glomerular Filtration Rate
Kidney
Succimer
Technetium Tc 99m Medronate
Bone and Bones
Pentetic Acid
Metabolic Bone Diseases
Creatinine
Spine
Urine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate. / Kim, S. E.; Cho, J. T.; Lee, D. S.; Chung, J. K.; Kim, Sungeun; Lee, M. C.; Lee, J. S.; Koh, C. S.

In: Journal of Korean Medical Science, Vol. 9, No. 1, 01.02.1994, p. 29-34.

Research output: Contribution to journalArticle

Kim, S. E. ; Cho, J. T. ; Lee, D. S. ; Chung, J. K. ; Kim, Sungeun ; Lee, M. C. ; Lee, J. S. ; Koh, C. S. / Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate. In: Journal of Korean Medical Science. 1994 ; Vol. 9, No. 1. pp. 29-34.
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abstract = "We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing in the urine. In Fanconi Syndrome the tubular reabsorption of DMSA may also be reduced, thus explaining the poor renal uptake in this patient. A 99mTc-MDP bone scan showed faint renal uptake and diffuse high uptake mainly in the spine, demonstrating that the metabolic bone disease associated with Fanconi Syndrome can be another mechanism for poor renal visualization on bone scan.",
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AU - Lee, J. S.

AU - Koh, C. S.

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