Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.

S. E. Kim, J. T. Cho, D. S. Lee, J. K. Chung, S. Kim, M. C. Lee, J. S. Lee, C. S. Koh

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing in the urine. In Fanconi Syndrome the tubular reabsorption of DMSA may also be reduced, thus explaining the poor renal uptake in this patient. A 99mTc-MDP bone scan showed faint renal uptake and diffuse high uptake mainly in the spine, demonstrating that the metabolic bone disease associated with Fanconi Syndrome can be another mechanism for poor renal visualization on bone scan.

    Original languageEnglish
    Pages (from-to)29-34
    Number of pages6
    JournalJournal of Korean medical science
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 1994 Feb

    ASJC Scopus subject areas

    • Medicine(all)

    Fingerprint

    Dive into the research topics of 'Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.'. Together they form a unique fingerprint.

    Cite this