Population pharmacokinetic analysis of piperacillin/tazobactam in Korean patients with acute infections

Pharmacokinetics-Pharmacodynamics of Antibiotics Working Group under Korean Society for Chemotherapy

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Abstract

Background: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients' characteristics, including race. The aim of this study was to investigate the population pharmacokinetic (PK) profiles of piperacillin and tazobactam in Korean patients with acute infections. Materials and Methods: At least four consecutive 2/0.25 g or 4/0.5 g doses of piperacillin/tazobactam (TZP) were intravenously infused over 1 h every 8 h for patients with creatinine clearance (CLcr) ≤50 mL/min or CLcr >50 mL/min, respectively. Blood samples from 33 patients at a steady-state were taken pre-dose and at 0 min, 30 min, and 4-6 h after the fourth infusion. The population PK analysis was conducted using a non-linear mixed-effects method. A likelihood ratio test was used to select significant covariates, with significance levels of P < 0.05 for selection and P < 0.01 for elimination. Results: Both piperacillin PK and tazobactam PK were well described by a two-compartment model with first-order elimination. Creatinine clearance and body weight, as covariates on clearance (CL) and volume of central compartment (V1), were selected among the covariates possibly affecting PK parameters of both drugs. CL was defined as CL = 2.9 + 4.03 × CLcr /47 for piperacillin and CL = 1.76 + 4.81 × CLcr /47 for tazobactam. V1 was defined as V1 = 19.5 × weight/60 for piperacillin and V1 = 22.6 × weight/60 for tazobactam. Conclusion: The PK profiles of TZP at a steady-state in Korean patients with acute infections were well described by a two-compartment model with first-order elimination. Both piperacillin and tazobactam clearances were significantly influenced by creatinine clearance.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalInfection and Chemotherapy
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

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Keywords

  • Clearance
  • Piperacillin
  • Population pharmacokinetics
  • Race
  • Tazobactam

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Pharmacokinetics-Pharmacodynamics of Antibiotics Working Group under Korean Society for Chemotherapy (2016). Population pharmacokinetic analysis of piperacillin/tazobactam in Korean patients with acute infections. Infection and Chemotherapy, 48(3), 209-215. https://doi.org/10.3947/ic.2016.48.3.209