Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics

In Kook Jun, Ju H. Song, Won Young Choi, Young-Hag Koh, Hyoun E. Kim, Hae W. Kim

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass-ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well-interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone-like apatite crystals were well mineralized on their surfaces. Osteoblast-like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass-coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.

Original languageEnglish
Pages (from-to)2703-2708
Number of pages6
JournalJournal of the American Ceramic Society
Volume90
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1
Externally publishedYes

Fingerprint

Apatites
wollastonite
Apatite
Glass ceramics
Durapatite
Hydroxyapatite
Scaffolds
ceramics
apatite
glass
coating
bioactivity
Coatings
Bioactive glass
Struts
Scaffolds (biology)
Bioactivity
body fluid
sponge
phosphatase

ASJC Scopus subject areas

  • Ceramics and Composites

Cite this

Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics. / Jun, In Kook; Song, Ju H.; Choi, Won Young; Koh, Young-Hag; Kim, Hyoun E.; Kim, Hae W.

In: Journal of the American Ceramic Society, Vol. 90, No. 9, 01.09.2007, p. 2703-2708.

Research output: Contribution to journalArticle

Jun, In Kook ; Song, Ju H. ; Choi, Won Young ; Koh, Young-Hag ; Kim, Hyoun E. ; Kim, Hae W. / Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics. In: Journal of the American Ceramic Society. 2007 ; Vol. 90, No. 9. pp. 2703-2708.
@article{928da0ab0bbb4e0c8804d0f366989b04,
title = "Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics",
abstract = "The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass-ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well-interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone-like apatite crystals were well mineralized on their surfaces. Osteoblast-like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass-coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.",
author = "Jun, {In Kook} and Song, {Ju H.} and Choi, {Won Young} and Young-Hag Koh and Kim, {Hyoun E.} and Kim, {Hae W.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1111/j.1551-2916.2007.01762.x",
language = "English",
volume = "90",
pages = "2703--2708",
journal = "Journal of the American Ceramic Society",
issn = "0002-7820",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics

AU - Jun, In Kook

AU - Song, Ju H.

AU - Choi, Won Young

AU - Koh, Young-Hag

AU - Kim, Hyoun E.

AU - Kim, Hae W.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass-ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well-interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone-like apatite crystals were well mineralized on their surfaces. Osteoblast-like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass-coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.

AB - The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass-ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well-interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone-like apatite crystals were well mineralized on their surfaces. Osteoblast-like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass-coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.

UR - http://www.scopus.com/inward/record.url?scp=34548481304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548481304&partnerID=8YFLogxK

U2 - 10.1111/j.1551-2916.2007.01762.x

DO - 10.1111/j.1551-2916.2007.01762.x

M3 - Article

AN - SCOPUS:34548481304

VL - 90

SP - 2703

EP - 2708

JO - Journal of the American Ceramic Society

JF - Journal of the American Ceramic Society

SN - 0002-7820

IS - 9

ER -