Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass-ceramics

In Kook Jun, Ju Ha Song, Won Young Choi, Young Hag Koh, Hyoun Ee Kim, Hae Won Kim

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass-ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well-interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone-like apatite crystals were well mineralized on their surfaces. Osteoblast-like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass-coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.

Original languageEnglish
Pages (from-to)2703-2708
Number of pages6
JournalJournal of the American Ceramic Society
Volume90
Issue number9
DOIs
Publication statusPublished - 2007 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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