Porous microwells for geometry-selective, large-scale particle arrays

Jae Jung Kim, Ki Wan Bong, Rathi L. Srinivas, Daniel Irimia, Patrick S. Doyle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The combination of microarray and microparticle technologies can result in synergistic effects for high-performance bioassays. Here, we present a porous microwell platform that is used to generate large-scale, ordered microparticle arrays. We guide particles to the microwells via hydrodynamic forces associated with fluid flow through open pores inside the microwell. After particles block the microwell perfectly, applied pressure deforms the microparticles to squeeze into the slightly smaller microwells. With this process, we demonstrated large-scale (10<sup>3</sup>-10<sup>4</sup>) particle assembly with high filling yield (94 %) and high assembling of initial particles (88 %). Sorting was based on size, modulus, and shape (specificity > 95 %).

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1763-1765
Number of pages3
ISBN (Print)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

Keywords

  • Large-scale array
  • Microparticles
  • Porous microwells
  • Sorting

ASJC Scopus subject areas

  • Control and Systems Engineering

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