Portal hypertensive enteropathy diagnosed by capsule endoscopy in cirrhotic patients

A nationwide multicenter study

Seong Ran Jeon, Jin Oh Kim, Ji Beom Kim, Byong Duk Ye, Dong Kyung Chang, Ki Nam Shim, Dae Young Cheung, Jin Soo Kim, Myung Gyu Choi, Hyun Joo Song, Yun Jeong Lim, Soo Jung Park, Ji Hyun Kim, Jeong Seop Moon, Yoon Tae Jeen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and Aim: Due to the limited data on portal hypertensive enteropathy (PHE), the prevalence of and clinical factors related to PHE remain unclear. This study determined the prevalence of PHE using capsule endoscopy (CE) and PHE-related clinical factors. Methods: This was a retrospective multicenter study using the Capsule Endoscopy Nationwide Database Registry. From 2,879 cases that underwent CE, 45 cirrhosis patients with portal hypertension (PH) were enrolled and divided into PHE (n = 18) and non-PHE (n = 27) groups. From computed tomography (CT) images, six secondary changes due to PH were scored to give a total CT score of 0-6. The main outcome variable was the prevalence of PHE and PHE-related clinical factors. Results: The prevalence of PHE was 40 %. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 % (vs. 7.4 %, p = 0.001) and varices in 38.9 % (vs. 0 %, p = 0.001). Active bleeding was observed in 16.6 and 3.7 %, respectively, but this difference was not significant. In the univariate analysis, Child-Turcotte-Pugh class C (p = 0.002) and a high CT score (>3 vs. <3, p = 0.004) were significantly associated with PHE. However, only a high CT score was significant in the multivariate analysis (odds ratio 11.19; 95 % confidence interval, 1.59-infinity; p = 0.040). Conclusions: The prevalence of PHE was 40 %, and it might be more prevalent in cirrhosis patients with PH who have a high CT score. CE is a useful diagnostic tool for evaluating PHE in cirrhosis patients with PH.

Original languageEnglish
Pages (from-to)1036-1041
Number of pages6
JournalDigestive Diseases and Sciences
Volume59
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Capsule Endoscopy
Multicenter Studies
Portal Hypertension
Tomography
Fibrosis
Angiodysplasia
Varicose Veins
Registries
Multivariate Analysis
Retrospective Studies
Cross-Sectional Studies
Odds Ratio
Databases
Confidence Intervals
Hemorrhage

Keywords

  • Capsule endoscopy
  • Enteropathy
  • Liver cirrhosis
  • Portal hypertension

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Portal hypertensive enteropathy diagnosed by capsule endoscopy in cirrhotic patients : A nationwide multicenter study. / Jeon, Seong Ran; Kim, Jin Oh; Kim, Ji Beom; Ye, Byong Duk; Chang, Dong Kyung; Shim, Ki Nam; Cheung, Dae Young; Kim, Jin Soo; Choi, Myung Gyu; Song, Hyun Joo; Lim, Yun Jeong; Park, Soo Jung; Kim, Ji Hyun; Moon, Jeong Seop; Jeen, Yoon Tae.

In: Digestive Diseases and Sciences, Vol. 59, No. 5, 01.01.2014, p. 1036-1041.

Research output: Contribution to journalArticle

Jeon, SR, Kim, JO, Kim, JB, Ye, BD, Chang, DK, Shim, KN, Cheung, DY, Kim, JS, Choi, MG, Song, HJ, Lim, YJ, Park, SJ, Kim, JH, Moon, JS & Jeen, YT 2014, 'Portal hypertensive enteropathy diagnosed by capsule endoscopy in cirrhotic patients: A nationwide multicenter study', Digestive Diseases and Sciences, vol. 59, no. 5, pp. 1036-1041. https://doi.org/10.1007/s10620-014-3036-3
Jeon, Seong Ran ; Kim, Jin Oh ; Kim, Ji Beom ; Ye, Byong Duk ; Chang, Dong Kyung ; Shim, Ki Nam ; Cheung, Dae Young ; Kim, Jin Soo ; Choi, Myung Gyu ; Song, Hyun Joo ; Lim, Yun Jeong ; Park, Soo Jung ; Kim, Ji Hyun ; Moon, Jeong Seop ; Jeen, Yoon Tae. / Portal hypertensive enteropathy diagnosed by capsule endoscopy in cirrhotic patients : A nationwide multicenter study. In: Digestive Diseases and Sciences. 2014 ; Vol. 59, No. 5. pp. 1036-1041.
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abstract = "Background and Aim: Due to the limited data on portal hypertensive enteropathy (PHE), the prevalence of and clinical factors related to PHE remain unclear. This study determined the prevalence of PHE using capsule endoscopy (CE) and PHE-related clinical factors. Methods: This was a retrospective multicenter study using the Capsule Endoscopy Nationwide Database Registry. From 2,879 cases that underwent CE, 45 cirrhosis patients with portal hypertension (PH) were enrolled and divided into PHE (n = 18) and non-PHE (n = 27) groups. From computed tomography (CT) images, six secondary changes due to PH were scored to give a total CT score of 0-6. The main outcome variable was the prevalence of PHE and PHE-related clinical factors. Results: The prevalence of PHE was 40 {\%}. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 {\%} (vs. 7.4 {\%}, p = 0.001) and varices in 38.9 {\%} (vs. 0 {\%}, p = 0.001). Active bleeding was observed in 16.6 and 3.7 {\%}, respectively, but this difference was not significant. In the univariate analysis, Child-Turcotte-Pugh class C (p = 0.002) and a high CT score (>3 vs. <3, p = 0.004) were significantly associated with PHE. However, only a high CT score was significant in the multivariate analysis (odds ratio 11.19; 95 {\%} confidence interval, 1.59-infinity; p = 0.040). Conclusions: The prevalence of PHE was 40 {\%}, and it might be more prevalent in cirrhosis patients with PH who have a high CT score. CE is a useful diagnostic tool for evaluating PHE in cirrhosis patients with PH.",
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AU - Jeon, Seong Ran

AU - Kim, Jin Oh

AU - Kim, Ji Beom

AU - Ye, Byong Duk

AU - Chang, Dong Kyung

AU - Shim, Ki Nam

AU - Cheung, Dae Young

AU - Kim, Jin Soo

AU - Choi, Myung Gyu

AU - Song, Hyun Joo

AU - Lim, Yun Jeong

AU - Park, Soo Jung

AU - Kim, Ji Hyun

AU - Moon, Jeong Seop

AU - Jeen, Yoon Tae

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N2 - Background and Aim: Due to the limited data on portal hypertensive enteropathy (PHE), the prevalence of and clinical factors related to PHE remain unclear. This study determined the prevalence of PHE using capsule endoscopy (CE) and PHE-related clinical factors. Methods: This was a retrospective multicenter study using the Capsule Endoscopy Nationwide Database Registry. From 2,879 cases that underwent CE, 45 cirrhosis patients with portal hypertension (PH) were enrolled and divided into PHE (n = 18) and non-PHE (n = 27) groups. From computed tomography (CT) images, six secondary changes due to PH were scored to give a total CT score of 0-6. The main outcome variable was the prevalence of PHE and PHE-related clinical factors. Results: The prevalence of PHE was 40 %. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 % (vs. 7.4 %, p = 0.001) and varices in 38.9 % (vs. 0 %, p = 0.001). Active bleeding was observed in 16.6 and 3.7 %, respectively, but this difference was not significant. In the univariate analysis, Child-Turcotte-Pugh class C (p = 0.002) and a high CT score (>3 vs. <3, p = 0.004) were significantly associated with PHE. However, only a high CT score was significant in the multivariate analysis (odds ratio 11.19; 95 % confidence interval, 1.59-infinity; p = 0.040). Conclusions: The prevalence of PHE was 40 %, and it might be more prevalent in cirrhosis patients with PH who have a high CT score. CE is a useful diagnostic tool for evaluating PHE in cirrhosis patients with PH.

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