Portal venous invasion: The single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma

Kang Kook Choi, Sung Hoon Kim, Sae-Byeol Choi, Jin Hong Lim, Gi Hong Choi, Jin Sub Choi, Kyung Sik Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background and Aim: Despite improvements of treatment in hepatocellular carcinoma (HCC), the recurrence rate after curative hepatic resection still remains remarkably high. An immediate recurrence of HCC after surgery is frustrating. We tried to clarify risks of immediate postoperative recurrence of HCC; that is, within 4months after curative hepatic resection. Methods: A total of 167 patients with HCC underwent hepatic resection; 60 had immediate postoperative recurrences (IPR group), and 107 had disease-free survival for more than 5years (DFS group). Variables were compared between the two groups. Results: Univariate analysis showed the following variables were significant risk factors for immediate postoperative recurrence of HCC: male sex, elevated serum aspartate aminotransferase level, greater amount of blood loss, longer operation time, worse tumor differentiation, higher tumor node metastasis stage, and presence of any of the following: intrahepatic metastasis, tumor-rupture, portal venous invasion, or microvascular invasion. In multivariate analysis, only portal venous invasion was a significant risk factor (odds ratio=3.2, P=0.03, standard error=0.5, Logistic regression analysis). Conclusions: Portal venous invasion may be the most significant risk factor for immediate postoperative recurrence of HCC. However, accurate assessment of this risk factor may require histological examination, limiting its utility as a preoperative predictor. Further research is necessary to definitively identify preoperative predictors.

Original languageEnglish
Pages (from-to)1646-1651
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number11
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Hepatocellular Carcinoma
Recurrence
Liver
Neoplasm Metastasis
Neoplasms
Aspartate Aminotransferases
Disease-Free Survival
Rupture
Multivariate Analysis
Logistic Models
Odds Ratio
Regression Analysis
Serum
Research
Therapeutics

Keywords

  • Hepatocellular carcinoma
  • Recurrence
  • Risk factor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Portal venous invasion : The single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma. / Choi, Kang Kook; Kim, Sung Hoon; Choi, Sae-Byeol; Lim, Jin Hong; Choi, Gi Hong; Choi, Jin Sub; Kim, Kyung Sik.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 11, 01.01.2011, p. 1646-1651.

Research output: Contribution to journalArticle

Choi, Kang Kook ; Kim, Sung Hoon ; Choi, Sae-Byeol ; Lim, Jin Hong ; Choi, Gi Hong ; Choi, Jin Sub ; Kim, Kyung Sik. / Portal venous invasion : The single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma. In: Journal of Gastroenterology and Hepatology (Australia). 2011 ; Vol. 26, No. 11. pp. 1646-1651.
@article{480f6241e70f40da8cc99d3358f801a1,
title = "Portal venous invasion: The single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma",
abstract = "Background and Aim: Despite improvements of treatment in hepatocellular carcinoma (HCC), the recurrence rate after curative hepatic resection still remains remarkably high. An immediate recurrence of HCC after surgery is frustrating. We tried to clarify risks of immediate postoperative recurrence of HCC; that is, within 4months after curative hepatic resection. Methods: A total of 167 patients with HCC underwent hepatic resection; 60 had immediate postoperative recurrences (IPR group), and 107 had disease-free survival for more than 5years (DFS group). Variables were compared between the two groups. Results: Univariate analysis showed the following variables were significant risk factors for immediate postoperative recurrence of HCC: male sex, elevated serum aspartate aminotransferase level, greater amount of blood loss, longer operation time, worse tumor differentiation, higher tumor node metastasis stage, and presence of any of the following: intrahepatic metastasis, tumor-rupture, portal venous invasion, or microvascular invasion. In multivariate analysis, only portal venous invasion was a significant risk factor (odds ratio=3.2, P=0.03, standard error=0.5, Logistic regression analysis). Conclusions: Portal venous invasion may be the most significant risk factor for immediate postoperative recurrence of HCC. However, accurate assessment of this risk factor may require histological examination, limiting its utility as a preoperative predictor. Further research is necessary to definitively identify preoperative predictors.",
keywords = "Hepatocellular carcinoma, Recurrence, Risk factor",
author = "Choi, {Kang Kook} and Kim, {Sung Hoon} and Sae-Byeol Choi and Lim, {Jin Hong} and Choi, {Gi Hong} and Choi, {Jin Sub} and Kim, {Kyung Sik}",
year = "2011",
month = "1",
day = "1",
doi = "10.1111/j.1440-1746.2011.06780.x",
language = "English",
volume = "26",
pages = "1646--1651",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Portal venous invasion

T2 - The single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma

AU - Choi, Kang Kook

AU - Kim, Sung Hoon

AU - Choi, Sae-Byeol

AU - Lim, Jin Hong

AU - Choi, Gi Hong

AU - Choi, Jin Sub

AU - Kim, Kyung Sik

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background and Aim: Despite improvements of treatment in hepatocellular carcinoma (HCC), the recurrence rate after curative hepatic resection still remains remarkably high. An immediate recurrence of HCC after surgery is frustrating. We tried to clarify risks of immediate postoperative recurrence of HCC; that is, within 4months after curative hepatic resection. Methods: A total of 167 patients with HCC underwent hepatic resection; 60 had immediate postoperative recurrences (IPR group), and 107 had disease-free survival for more than 5years (DFS group). Variables were compared between the two groups. Results: Univariate analysis showed the following variables were significant risk factors for immediate postoperative recurrence of HCC: male sex, elevated serum aspartate aminotransferase level, greater amount of blood loss, longer operation time, worse tumor differentiation, higher tumor node metastasis stage, and presence of any of the following: intrahepatic metastasis, tumor-rupture, portal venous invasion, or microvascular invasion. In multivariate analysis, only portal venous invasion was a significant risk factor (odds ratio=3.2, P=0.03, standard error=0.5, Logistic regression analysis). Conclusions: Portal venous invasion may be the most significant risk factor for immediate postoperative recurrence of HCC. However, accurate assessment of this risk factor may require histological examination, limiting its utility as a preoperative predictor. Further research is necessary to definitively identify preoperative predictors.

AB - Background and Aim: Despite improvements of treatment in hepatocellular carcinoma (HCC), the recurrence rate after curative hepatic resection still remains remarkably high. An immediate recurrence of HCC after surgery is frustrating. We tried to clarify risks of immediate postoperative recurrence of HCC; that is, within 4months after curative hepatic resection. Methods: A total of 167 patients with HCC underwent hepatic resection; 60 had immediate postoperative recurrences (IPR group), and 107 had disease-free survival for more than 5years (DFS group). Variables were compared between the two groups. Results: Univariate analysis showed the following variables were significant risk factors for immediate postoperative recurrence of HCC: male sex, elevated serum aspartate aminotransferase level, greater amount of blood loss, longer operation time, worse tumor differentiation, higher tumor node metastasis stage, and presence of any of the following: intrahepatic metastasis, tumor-rupture, portal venous invasion, or microvascular invasion. In multivariate analysis, only portal venous invasion was a significant risk factor (odds ratio=3.2, P=0.03, standard error=0.5, Logistic regression analysis). Conclusions: Portal venous invasion may be the most significant risk factor for immediate postoperative recurrence of HCC. However, accurate assessment of this risk factor may require histological examination, limiting its utility as a preoperative predictor. Further research is necessary to definitively identify preoperative predictors.

KW - Hepatocellular carcinoma

KW - Recurrence

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=80054886995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054886995&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2011.06780.x

DO - 10.1111/j.1440-1746.2011.06780.x

M3 - Article

C2 - 21592228

AN - SCOPUS:80054886995

VL - 26

SP - 1646

EP - 1651

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 11

ER -