Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis

Mi-Mi Oh, Ji Yun Chae, Jin Wook Kim, Jong Wook Kim, Cheol Yong Yoon, Min Gu Park, Du Geon Moon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. Methods: From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patients with acute prostatitis were enrolled. Acute prostatitis was defined as a fever greater than 38°C, pyuria, and tenderness on digital rectal examination. Urine and blood cultures were tested for antibiotic susceptibility. Laboratory and clinical variables according to the presence of ESBL were analyzed. Results: Blood or urine culture was positive in 23 patients. The most common strain was Escherichia coli. Sixteen patients showed ESBL-positive and 18 patients were quinolone-resistant. Thirteen of 16 patients with ESBL-positive strains showed quinolone resistance, and 13 of 18 patients with quinolone resistance were ESBL-positive (P =.621). Besides imipenem, all ESBL-positive patients were susceptible to amikacin and were highly susceptible to cefoxitin and amoxicillin/clavulanic acid. The prevalence of ESBL-positive strains has tended to increase since 2006. Patients with ESBL had higher peak fever, white blood cell count, absolute neutrophil count, and longer duration of fever and hospitalization. The progression rate to chronic prostatitis was significantly higher in ESBL-positive patients (4/16 vs 0/17, P =.044). Conclusion: Since 2006, ESBL strains have been increasing, and the presence of ESBL showed more detrimental effects on the clinical course of the patients, resulting in a higher rate of progression to chronic prostatitis.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalUrology
Volume81
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Prostatitis
Prostate
Biopsy
Quinolones
Fever
Urine
Pyuria
Amoxicillin-Potassium Clavulanate Combination
Cefoxitin
Digital Rectal Examination
Amikacin
Imipenem
Leukocyte Count
Hospitalization
Neutrophils

ASJC Scopus subject areas

  • Urology

Cite this

Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis. / Oh, Mi-Mi; Chae, Ji Yun; Kim, Jin Wook; Kim, Jong Wook; Yoon, Cheol Yong; Park, Min Gu; Moon, Du Geon.

In: Urology, Vol. 81, No. 6, 01.06.2013, p. 1209-1212.

Research output: Contribution to journalArticle

Oh, Mi-Mi ; Chae, Ji Yun ; Kim, Jin Wook ; Kim, Jong Wook ; Yoon, Cheol Yong ; Park, Min Gu ; Moon, Du Geon. / Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis. In: Urology. 2013 ; Vol. 81, No. 6. pp. 1209-1212.
@article{96fecb5d5a814f14b7d6bb84344930ef,
title = "Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis",
abstract = "Objective: To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. Methods: From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patients with acute prostatitis were enrolled. Acute prostatitis was defined as a fever greater than 38°C, pyuria, and tenderness on digital rectal examination. Urine and blood cultures were tested for antibiotic susceptibility. Laboratory and clinical variables according to the presence of ESBL were analyzed. Results: Blood or urine culture was positive in 23 patients. The most common strain was Escherichia coli. Sixteen patients showed ESBL-positive and 18 patients were quinolone-resistant. Thirteen of 16 patients with ESBL-positive strains showed quinolone resistance, and 13 of 18 patients with quinolone resistance were ESBL-positive (P =.621). Besides imipenem, all ESBL-positive patients were susceptible to amikacin and were highly susceptible to cefoxitin and amoxicillin/clavulanic acid. The prevalence of ESBL-positive strains has tended to increase since 2006. Patients with ESBL had higher peak fever, white blood cell count, absolute neutrophil count, and longer duration of fever and hospitalization. The progression rate to chronic prostatitis was significantly higher in ESBL-positive patients (4/16 vs 0/17, P =.044). Conclusion: Since 2006, ESBL strains have been increasing, and the presence of ESBL showed more detrimental effects on the clinical course of the patients, resulting in a higher rate of progression to chronic prostatitis.",
author = "Mi-Mi Oh and Chae, {Ji Yun} and Kim, {Jin Wook} and Kim, {Jong Wook} and Yoon, {Cheol Yong} and Park, {Min Gu} and Moon, {Du Geon}",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.urology.2013.02.040",
language = "English",
volume = "81",
pages = "1209--1212",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis

AU - Oh, Mi-Mi

AU - Chae, Ji Yun

AU - Kim, Jin Wook

AU - Kim, Jong Wook

AU - Yoon, Cheol Yong

AU - Park, Min Gu

AU - Moon, Du Geon

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Objective: To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. Methods: From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patients with acute prostatitis were enrolled. Acute prostatitis was defined as a fever greater than 38°C, pyuria, and tenderness on digital rectal examination. Urine and blood cultures were tested for antibiotic susceptibility. Laboratory and clinical variables according to the presence of ESBL were analyzed. Results: Blood or urine culture was positive in 23 patients. The most common strain was Escherichia coli. Sixteen patients showed ESBL-positive and 18 patients were quinolone-resistant. Thirteen of 16 patients with ESBL-positive strains showed quinolone resistance, and 13 of 18 patients with quinolone resistance were ESBL-positive (P =.621). Besides imipenem, all ESBL-positive patients were susceptible to amikacin and were highly susceptible to cefoxitin and amoxicillin/clavulanic acid. The prevalence of ESBL-positive strains has tended to increase since 2006. Patients with ESBL had higher peak fever, white blood cell count, absolute neutrophil count, and longer duration of fever and hospitalization. The progression rate to chronic prostatitis was significantly higher in ESBL-positive patients (4/16 vs 0/17, P =.044). Conclusion: Since 2006, ESBL strains have been increasing, and the presence of ESBL showed more detrimental effects on the clinical course of the patients, resulting in a higher rate of progression to chronic prostatitis.

AB - Objective: To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. Methods: From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patients with acute prostatitis were enrolled. Acute prostatitis was defined as a fever greater than 38°C, pyuria, and tenderness on digital rectal examination. Urine and blood cultures were tested for antibiotic susceptibility. Laboratory and clinical variables according to the presence of ESBL were analyzed. Results: Blood or urine culture was positive in 23 patients. The most common strain was Escherichia coli. Sixteen patients showed ESBL-positive and 18 patients were quinolone-resistant. Thirteen of 16 patients with ESBL-positive strains showed quinolone resistance, and 13 of 18 patients with quinolone resistance were ESBL-positive (P =.621). Besides imipenem, all ESBL-positive patients were susceptible to amikacin and were highly susceptible to cefoxitin and amoxicillin/clavulanic acid. The prevalence of ESBL-positive strains has tended to increase since 2006. Patients with ESBL had higher peak fever, white blood cell count, absolute neutrophil count, and longer duration of fever and hospitalization. The progression rate to chronic prostatitis was significantly higher in ESBL-positive patients (4/16 vs 0/17, P =.044). Conclusion: Since 2006, ESBL strains have been increasing, and the presence of ESBL showed more detrimental effects on the clinical course of the patients, resulting in a higher rate of progression to chronic prostatitis.

UR - http://www.scopus.com/inward/record.url?scp=84878596233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878596233&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2013.02.040

DO - 10.1016/j.urology.2013.02.040

M3 - Article

C2 - 23601450

AN - SCOPUS:84878596233

VL - 81

SP - 1209

EP - 1212

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -