Possible association between serotonin transporter gene polymorphism and suicide behavior in major depressive disorder

Hwa Young Lee, Jin Pyo Hong, Jung A. Hwang, Heon-Jeong Lee, Ho-Kyoung Yoon, Bun Hee Lee, Yong Ku Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).

Methods Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton’s 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.

Results Although not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.

Conclusion These results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalPsychiatry Investigation
Volume12
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Serotonin Plasma Membrane Transport Proteins
Major Depressive Disorder
Suicide
Alleles
Genes
Genotype
Gene Frequency
Introns
Haplotypes
Depression

Keywords

  • Haplotype
  • Major depressive disorder
  • Polymorphism
  • Serotonin transporter
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Possible association between serotonin transporter gene polymorphism and suicide behavior in major depressive disorder. / Lee, Hwa Young; Hong, Jin Pyo; Hwang, Jung A.; Lee, Heon-Jeong; Yoon, Ho-Kyoung; Lee, Bun Hee; Kim, Yong Ku.

In: Psychiatry Investigation, Vol. 12, No. 1, 01.01.2015, p. 136-141.

Research output: Contribution to journalArticle

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AB - Objective The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).Methods Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton’s 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.Results Although not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.Conclusion These results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.

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