Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a - 2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the - 2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p = 0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p = 0.046). This finding supports the presence of a relationship between the - 2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
|Number of pages||4|
|Journal||Progress in Neuro-Psychopharmacology and Biological Psychiatry|
|Publication status||Published - 2008 Jan 1|
- Leptin gene
- Weight gain
ASJC Scopus subject areas
- Biological Psychiatry