Possible association between the - 2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain

Seung Gul Kang, Heon Jeong Lee, Young Min Park, Jung Eun Choi, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a - 2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the - 2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p = 0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p = 0.046). This finding supports the presence of a relationship between the - 2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

Keywords

  • Leptin gene
  • Olanzapine
  • Polymorphism
  • Schizophrenia
  • Weight gain

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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