Possible association between the - 2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain

Seung Gul Kang, Heon-Jeong Lee, Young Min Park, Jung Eun Choi, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

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49 Citations (Scopus)


Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a - 2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the - 2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p = 0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p = 0.046). This finding supports the presence of a relationship between the - 2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
Publication statusPublished - 2008 Jan 1



  • Leptin gene
  • Olanzapine
  • Polymorphism
  • Schizophrenia
  • Weight gain

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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