Possible association between the - 2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain

Seung Gul Kang, Heon-Jeong Lee, Young Min Park, Jung Eun Choi, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a - 2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the - 2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p = 0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p = 0.046). This finding supports the presence of a relationship between the - 2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

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olanzapine
Leptin
Weight Gain
Genes
Single Nucleotide Polymorphism
Antipsychotic Agents
Genotype
Therapeutics
Weights and Measures

Keywords

  • Leptin gene
  • Olanzapine
  • Polymorphism
  • Schizophrenia
  • Weight gain

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Possible association between the - 2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain. / Kang, Seung Gul; Lee, Heon-Jeong; Park, Young Min; Choi, Jung Eun; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Kim, Leen.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 1, 01.01.2008, p. 160-163.

Research output: Contribution to journalArticle

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