Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia

Concetta Crisafulli; Alberto Chiesa; Changsu Han; Soo Jung Lee; Dong Suk Shim; Beatrice Balzarro; Costanza Andrisano; Antonina Sidoti; Ashwin A. Patkar; Chi Un Pae; Alessandro Serretti

doi:10.1016/j.neulet.2011.12.013

Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia

Concetta Crisafulli, Alberto Chiesa, Changsu Han, Soo Jung Lee, Dong Suk Shim, Beatrice Balzarro, Costanza Andrisano, Antonina Sidoti, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

Department of Psychiatry

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM. All patients were assessed for the severity of illness at baseline and at discharge by means of the Positive and Negative Symptoms Scale (PANSS). Our findings suggest the lack of influence of SNPs under investigation in the present study on the susceptibility to SKZ and on the response to antipsychotics. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Neuroscience Letters
Volume	508
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.12.013
Publication status	Published - 2012 Feb 2

Keywords

CREB1
CREBBP
CREM
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2011.12.013

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Crisafulli, C., Chiesa, A., Han, C., Lee, S. J., Suk Shim, D., Balzarro, B., Andrisano, C., Sidoti, A., Patkar, A. A., Pae, C. U., & Serretti, A. (2012). Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia. Neuroscience Letters, 508(1), 37-41. https://doi.org/10.1016/j.neulet.2011.12.013

Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia. / Crisafulli, Concetta; Chiesa, Alberto; Han, Changsu; Lee, Soo Jung; Suk Shim, Dong; Balzarro, Beatrice; Andrisano, Costanza; Sidoti, Antonina; Patkar, Ashwin A.; Pae, Chi Un; Serretti, Alessandro.

In: Neuroscience Letters, Vol. 508, No. 1, 02.02.2012, p. 37-41.

Research output: Contribution to journal › Article

Crisafulli, Concetta ; Chiesa, Alberto ; Han, Changsu ; Lee, Soo Jung ; Suk Shim, Dong ; Balzarro, Beatrice ; Andrisano, Costanza ; Sidoti, Antonina ; Patkar, Ashwin A. ; Pae, Chi Un ; Serretti, Alessandro. / Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia. In: Neuroscience Letters. 2012 ; Vol. 508, No. 1. pp. 37-41.

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