TY - JOUR
T1 - Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia
AU - Crisafulli, Concetta
AU - Chiesa, Alberto
AU - Han, Changsu
AU - Lee, Soo Jung
AU - Suk Shim, Dong
AU - Balzarro, Beatrice
AU - Andrisano, Costanza
AU - Sidoti, Antonina
AU - Patkar, Ashwin A.
AU - Pae, Chi Un
AU - Serretti, Alessandro
N1 - Funding Information:
This work was supported by grants from the Medical Research Center, Korea Science and Engineering Foundation, Republic of Korea ( R13-2002-005-04001-0 ).
PY - 2012/2/2
Y1 - 2012/2/2
N2 - The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM. All patients were assessed for the severity of illness at baseline and at discharge by means of the Positive and Negative Symptoms Scale (PANSS). Our findings suggest the lack of influence of SNPs under investigation in the present study on the susceptibility to SKZ and on the response to antipsychotics. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
AB - The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM. All patients were assessed for the severity of illness at baseline and at discharge by means of the Positive and Negative Symptoms Scale (PANSS). Our findings suggest the lack of influence of SNPs under investigation in the present study on the susceptibility to SKZ and on the response to antipsychotics. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
KW - CREB1
KW - CREBBP
KW - CREM
KW - Schizophrenia
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U2 - 10.1016/j.neulet.2011.12.013
DO - 10.1016/j.neulet.2011.12.013
M3 - Article
C2 - 22198373
AN - SCOPUS:84855935296
VL - 508
SP - 37
EP - 41
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -