Possible role of nerve growth factor in the pathogenesis of alcohol dependence

Su Jung Yoon, Sungwon Roh, Heejin Lee, Ji Youl Lee, Bun Hee Lee, Yong Ku Kim, Dai Jin Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Recent studies have raised the possibility that nerve growth factor (NGF) is abnormally regulated in the central nervous system (CNS) of animal models of chronic ethanol treatment. The goals of this study were to determine whether prolonged alcohol consumption is associated with the plasma NGF levels and to assess the effect of a positive family history of alcohol dependence on plasma NGF levels in the alcohol-dependent patients. Methods: We used the enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of peripheral NGF in patients with alcohol dependence and in a control group. Results: The plasma NGF concentrations in the alcohol-dependent patients were significantly lower than in the controls (71.9 vs 110.5 pg/mL, respectively). Moreover, the alcohol-dependent patients with positive family histories showed a greater decrease in their NGF levels than those subjects with negative family histories (64.7 vs 83.3 pg/mL, respectively). Conclusions: Our study suggests that the NGF levels may be a trait marker for the development of alcohol dependence.

Original languageEnglish
Pages (from-to)1060-1065
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume30
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1

Fingerprint

Nerve Growth Factor
Alcoholism
Alcohols
Plasmas
Immunosorbents
Neurology
Alcohol Drinking
Assays
Animals
Ethanol
Central Nervous System
Animal Models
Enzyme-Linked Immunosorbent Assay
Control Groups
Enzymes

Keywords

  • Alcohol Dependence
  • Family History
  • Nerve Growth Factor
  • Neurotrophin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Possible role of nerve growth factor in the pathogenesis of alcohol dependence. / Yoon, Su Jung; Roh, Sungwon; Lee, Heejin; Lee, Ji Youl; Lee, Bun Hee; Kim, Yong Ku; Kim, Dai Jin.

In: Alcoholism: Clinical and Experimental Research, Vol. 30, No. 6, 01.06.2006, p. 1060-1065.

Research output: Contribution to journalArticle

Yoon, Su Jung ; Roh, Sungwon ; Lee, Heejin ; Lee, Ji Youl ; Lee, Bun Hee ; Kim, Yong Ku ; Kim, Dai Jin. / Possible role of nerve growth factor in the pathogenesis of alcohol dependence. In: Alcoholism: Clinical and Experimental Research. 2006 ; Vol. 30, No. 6. pp. 1060-1065.
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