Post-polymerization modification reactions of poly(glycidyl methacrylate)s

Ezzah M. Muzammil, Anzar Khan, Mihaiela C. Stuparu

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Post-polymerisation modification of poly(glycidyl methacrylate) (PGMA) through the nucleophilic ring opening reactions of the pendent epoxide groups allows for the installation of a variety of functionalities onto the reactive scaffold. The primary modification processes involve amine-epoxy, thiol-epoxy, azide-epoxy, acid-epoxy, and hydrolysis reactions. In all cases, sequential post-synthesis modification reactions can also be carried out if multiply-functionalised polymers are required. This, in particular, includes reactions of the hydroxyl group(s) that come into being through the initial oxirane ring-opening reaction. The overall flexibility of these functionalisations, coupled with the commercial availability of glycidyl methacrylate monomer, its controlled polymerisation behaviour through free radical polymerisation methods and high shelf life of the resulting polymers makes PGMA one of the most adaptable reactive scaffolds in polymer chemistry. In this review article, our aim is to discuss the fundamental aspects of the epoxy ring-opening reactions and highlight the utilitarian nature of PGMA by addressing the range of chemistry that has been used to transform this simple structure into a plethora of customised functional polymers.

Original languageEnglish
Pages (from-to)55874-55884
Number of pages11
JournalRSC Advances
Volume7
Issue number88
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Polymers
Polymerization
Scaffolds
Ethylene Oxide
Functional polymers
Azides
Epoxy Compounds
Free radical polymerization
Sulfhydryl Compounds
Hydroxyl Radical
Amines
Hydrolysis
Monomers
Availability
Acids
polyglycidyl methacrylate
glycidyl methacrylate

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Post-polymerization modification reactions of poly(glycidyl methacrylate)s. / Muzammil, Ezzah M.; Khan, Anzar; Stuparu, Mihaiela C.

In: RSC Advances, Vol. 7, No. 88, 01.01.2017, p. 55874-55884.

Research output: Contribution to journalReview article

Muzammil, Ezzah M. ; Khan, Anzar ; Stuparu, Mihaiela C. / Post-polymerization modification reactions of poly(glycidyl methacrylate)s. In: RSC Advances. 2017 ; Vol. 7, No. 88. pp. 55874-55884.
@article{f69be01f5edc47ff88c1952c500a8026,
title = "Post-polymerization modification reactions of poly(glycidyl methacrylate)s",
abstract = "Post-polymerisation modification of poly(glycidyl methacrylate) (PGMA) through the nucleophilic ring opening reactions of the pendent epoxide groups allows for the installation of a variety of functionalities onto the reactive scaffold. The primary modification processes involve amine-epoxy, thiol-epoxy, azide-epoxy, acid-epoxy, and hydrolysis reactions. In all cases, sequential post-synthesis modification reactions can also be carried out if multiply-functionalised polymers are required. This, in particular, includes reactions of the hydroxyl group(s) that come into being through the initial oxirane ring-opening reaction. The overall flexibility of these functionalisations, coupled with the commercial availability of glycidyl methacrylate monomer, its controlled polymerisation behaviour through free radical polymerisation methods and high shelf life of the resulting polymers makes PGMA one of the most adaptable reactive scaffolds in polymer chemistry. In this review article, our aim is to discuss the fundamental aspects of the epoxy ring-opening reactions and highlight the utilitarian nature of PGMA by addressing the range of chemistry that has been used to transform this simple structure into a plethora of customised functional polymers.",
author = "Muzammil, {Ezzah M.} and Anzar Khan and Stuparu, {Mihaiela C.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1039/c7ra11093f",
language = "English",
volume = "7",
pages = "55874--55884",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "88",

}

TY - JOUR

T1 - Post-polymerization modification reactions of poly(glycidyl methacrylate)s

AU - Muzammil, Ezzah M.

AU - Khan, Anzar

AU - Stuparu, Mihaiela C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Post-polymerisation modification of poly(glycidyl methacrylate) (PGMA) through the nucleophilic ring opening reactions of the pendent epoxide groups allows for the installation of a variety of functionalities onto the reactive scaffold. The primary modification processes involve amine-epoxy, thiol-epoxy, azide-epoxy, acid-epoxy, and hydrolysis reactions. In all cases, sequential post-synthesis modification reactions can also be carried out if multiply-functionalised polymers are required. This, in particular, includes reactions of the hydroxyl group(s) that come into being through the initial oxirane ring-opening reaction. The overall flexibility of these functionalisations, coupled with the commercial availability of glycidyl methacrylate monomer, its controlled polymerisation behaviour through free radical polymerisation methods and high shelf life of the resulting polymers makes PGMA one of the most adaptable reactive scaffolds in polymer chemistry. In this review article, our aim is to discuss the fundamental aspects of the epoxy ring-opening reactions and highlight the utilitarian nature of PGMA by addressing the range of chemistry that has been used to transform this simple structure into a plethora of customised functional polymers.

AB - Post-polymerisation modification of poly(glycidyl methacrylate) (PGMA) through the nucleophilic ring opening reactions of the pendent epoxide groups allows for the installation of a variety of functionalities onto the reactive scaffold. The primary modification processes involve amine-epoxy, thiol-epoxy, azide-epoxy, acid-epoxy, and hydrolysis reactions. In all cases, sequential post-synthesis modification reactions can also be carried out if multiply-functionalised polymers are required. This, in particular, includes reactions of the hydroxyl group(s) that come into being through the initial oxirane ring-opening reaction. The overall flexibility of these functionalisations, coupled with the commercial availability of glycidyl methacrylate monomer, its controlled polymerisation behaviour through free radical polymerisation methods and high shelf life of the resulting polymers makes PGMA one of the most adaptable reactive scaffolds in polymer chemistry. In this review article, our aim is to discuss the fundamental aspects of the epoxy ring-opening reactions and highlight the utilitarian nature of PGMA by addressing the range of chemistry that has been used to transform this simple structure into a plethora of customised functional polymers.

UR - http://www.scopus.com/inward/record.url?scp=85038363146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038363146&partnerID=8YFLogxK

U2 - 10.1039/c7ra11093f

DO - 10.1039/c7ra11093f

M3 - Review article

AN - SCOPUS:85038363146

VL - 7

SP - 55874

EP - 55884

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 88

ER -