Postnatal early overnutrition causes long-term renal decline in aging male rats

Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee

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12 Citations (Scopus)

Abstract

Background:We evaluated the influence of postnatal early overnutrition on renal pathophysiological changes in aging rats.Methods:Three or 10 male pups per mother were assigned to either the small litter (SL) or normal litter (control) groups, respectively, during the first 21 d of life. The effects of early postnatal overnutrition were determined at 12 mo.Results:SL rats weighed more than controls between 4 d and 6 mo of age (P < 0.05). However, between 6 and 12 mo, body weights in both groups were not different. In the SL group, at 12 mo, systolic blood pressure was higher and creatinine clearance was lower than the same in controls (P < 0.05). Numbers of CD68 (ED1)-positive macrophages and apoptotic cells in renal cortex were higher in SL rats (P < 0.05). Furthermore, index scores for glomerulosclerosis and tubulointerstitial fibrosis were higher in the SL group (P < 0.05). Significantly less glomeruli per section area were found in aging SL rats (P < 0.05). Immunoblotting and immunohistochemistry showed decreased intrarenal renin expression in SL rats (P < 0.05).Conclusion:Early postnatal overnutrition can potentiate structural and functional abnormalities in the aging kidney and can lead to systolic hypertension with reduced intrarenal renin activity.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalPediatric Research
Volume75
Issue number2
DOIs
Publication statusPublished - 2014 Feb

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Yim, H. E., Yoo, K. H., Bae, I. S., Hong, Y. S., & Lee, J. W. (2014). Postnatal early overnutrition causes long-term renal decline in aging male rats. Pediatric Research, 75(2), 259-265. https://doi.org/10.1038/pr.2013.223