Postoperative neck ultrasonography surveillance after thyroidectomy in patients with medullary thyroid carcinoma: A multicenter study

Hye Shin Ahn, Dong Wook Kim, Yoo Jin Lee, Chang Yoon Lee, Ji hoon Kim, Yoon Jung Choi, Song Lee, Inseon Ryoo, Jung Yin Huh, Jin Yong Sung, Jin Young Kwak, Hye Jin Baek

Research output: Contribution to journalArticle

Abstract

Background: For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC. Methods: A total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups. Results: Of the 86 patients, 22 (25.6%) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50%) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6-128 months) and 2.6 ± 2.3 (range, 1-8), respectively. On follow-up US, 6 (54.5%, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013). Conclusion: For detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4-10 years after thyroid surgery.

Original languageEnglish
Article number102
JournalFrontiers in Endocrinology
Volume9
Issue numberMAR
DOIs
Publication statusPublished - 2018 Mar 15

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Thyroidectomy
Multicenter Studies
Ultrasonography
Neck
Recurrence
Neoplasms
Thyroid Gland
Medullary Thyroid cancer

Keywords

  • Malignancy
  • Medullary thyroid carcinoma
  • Recurrence
  • Surveillance
  • Thyroid
  • Ultrasonography

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Postoperative neck ultrasonography surveillance after thyroidectomy in patients with medullary thyroid carcinoma : A multicenter study. / Ahn, Hye Shin; Kim, Dong Wook; Lee, Yoo Jin; Lee, Chang Yoon; Kim, Ji hoon; Choi, Yoon Jung; Lee, Song; Ryoo, Inseon; Huh, Jung Yin; Sung, Jin Yong; Kwak, Jin Young; Baek, Hye Jin.

In: Frontiers in Endocrinology, Vol. 9, No. MAR, 102, 15.03.2018.

Research output: Contribution to journalArticle

Ahn, Hye Shin ; Kim, Dong Wook ; Lee, Yoo Jin ; Lee, Chang Yoon ; Kim, Ji hoon ; Choi, Yoon Jung ; Lee, Song ; Ryoo, Inseon ; Huh, Jung Yin ; Sung, Jin Yong ; Kwak, Jin Young ; Baek, Hye Jin. / Postoperative neck ultrasonography surveillance after thyroidectomy in patients with medullary thyroid carcinoma : A multicenter study. In: Frontiers in Endocrinology. 2018 ; Vol. 9, No. MAR.
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abstract = "Background: For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC. Methods: A total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups. Results: Of the 86 patients, 22 (25.6{\%}) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50{\%}) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6-128 months) and 2.6 ± 2.3 (range, 1-8), respectively. On follow-up US, 6 (54.5{\%}, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013). Conclusion: For detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4-10 years after thyroid surgery.",
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T1 - Postoperative neck ultrasonography surveillance after thyroidectomy in patients with medullary thyroid carcinoma

T2 - A multicenter study

AU - Ahn, Hye Shin

AU - Kim, Dong Wook

AU - Lee, Yoo Jin

AU - Lee, Chang Yoon

AU - Kim, Ji hoon

AU - Choi, Yoon Jung

AU - Lee, Song

AU - Ryoo, Inseon

AU - Huh, Jung Yin

AU - Sung, Jin Yong

AU - Kwak, Jin Young

AU - Baek, Hye Jin

PY - 2018/3/15

Y1 - 2018/3/15

N2 - Background: For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC. Methods: A total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups. Results: Of the 86 patients, 22 (25.6%) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50%) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6-128 months) and 2.6 ± 2.3 (range, 1-8), respectively. On follow-up US, 6 (54.5%, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013). Conclusion: For detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4-10 years after thyroid surgery.

AB - Background: For detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC. Methods: A total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups. Results: Of the 86 patients, 22 (25.6%) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50%) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6-128 months) and 2.6 ± 2.3 (range, 1-8), respectively. On follow-up US, 6 (54.5%, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013). Conclusion: For detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4-10 years after thyroid surgery.

KW - Malignancy

KW - Medullary thyroid carcinoma

KW - Recurrence

KW - Surveillance

KW - Thyroid

KW - Ultrasonography

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