TY - JOUR
T1 - Postpartum haemorrhage requiring transfusion and risk of cardiovascular disease later in life
T2 - a retrospective cohort study
AU - Cho, G. J.
AU - Lee, K. M.
AU - Kim, H. Y.
AU - Han, S. W.
AU - Oh, M. J.
AU - Chiec, L.
AU - Chae, Y. K.
N1 - Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant no. HI19C0502).
Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant no. HI19C0502).
Publisher Copyright:
© 2020 John Wiley & Sons Ltd.
PY - 2021/3
Y1 - 2021/3
N2 - Objective: To determine whether postpartum haemorrhage (PPH) is associated with cardiovascular disease (CVD), including cerebrovascular and ischaemic heart disease beyond the peripartum period. Design: Population-based cohort study. Setting: Merged databases of the Korea National Health Insurance (KNHI) claims, National Health Screening Examination and National Health Screening Program for Infants and Children. Population: Women who gave birth in 2007 in the Republic of Korea and who were tracked through to 2015 for the occurrence of CVD. Methods: Patients were identified and the occurrences of PPH and transfusion were determined using the KNHI claims database. The occurrence of CVD was tracked through 2015 using codes from the International Classification of Diseases, tenth revision (ICD-10). Main outcome measures: The risk of CVD after PPH. Results: Among 150 381 women who gave birth during the study period, 9107 were diagnosed with PPH and 899 were treated with transfusion. The risk of CVD in women with PPH was no different than in women without PPH, after adjustment (HR 1.03, 95% CI 0.93–1.13). The risk of CVD in women with PPH requiring transfusion was significantly increased compared with women without PPH, after adjustment (HR 1.60, 95% CI 1.25–2.06). The risk of CVD in women with PPH without transfusion was not significantly different compared with women without PPH (HR 0.96, 95% CI 0.86–1.07). Conclusions: Postpartum haemorrhage (PPH) requiring transfusion is associated with an increased risk of CVD. Guidelines for management should be established, and further studies on the mechanisms involved should be conducted. Tweetable abstract: PPH requiring transfusion is associated with an increased risk of CVD.
AB - Objective: To determine whether postpartum haemorrhage (PPH) is associated with cardiovascular disease (CVD), including cerebrovascular and ischaemic heart disease beyond the peripartum period. Design: Population-based cohort study. Setting: Merged databases of the Korea National Health Insurance (KNHI) claims, National Health Screening Examination and National Health Screening Program for Infants and Children. Population: Women who gave birth in 2007 in the Republic of Korea and who were tracked through to 2015 for the occurrence of CVD. Methods: Patients were identified and the occurrences of PPH and transfusion were determined using the KNHI claims database. The occurrence of CVD was tracked through 2015 using codes from the International Classification of Diseases, tenth revision (ICD-10). Main outcome measures: The risk of CVD after PPH. Results: Among 150 381 women who gave birth during the study period, 9107 were diagnosed with PPH and 899 were treated with transfusion. The risk of CVD in women with PPH was no different than in women without PPH, after adjustment (HR 1.03, 95% CI 0.93–1.13). The risk of CVD in women with PPH requiring transfusion was significantly increased compared with women without PPH, after adjustment (HR 1.60, 95% CI 1.25–2.06). The risk of CVD in women with PPH without transfusion was not significantly different compared with women without PPH (HR 0.96, 95% CI 0.86–1.07). Conclusions: Postpartum haemorrhage (PPH) requiring transfusion is associated with an increased risk of CVD. Guidelines for management should be established, and further studies on the mechanisms involved should be conducted. Tweetable abstract: PPH requiring transfusion is associated with an increased risk of CVD.
KW - Cardiovascular disease
KW - postpartum haemorrhage
KW - transfusion
UR - http://www.scopus.com/inward/record.url?scp=85097944863&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.16515
DO - 10.1111/1471-0528.16515
M3 - Article
C2 - 32946626
AN - SCOPUS:85097944863
VL - 128
SP - 738
EP - 744
JO - The Journal of obstetrics and gynaecology of the British Empire
JF - The Journal of obstetrics and gynaecology of the British Empire
SN - 1470-0328
IS - 4
ER -