Poststroke depression and emotional incontinence

Factors related to acute and subacute stages

S. Choi-Kwon, K. Han, S. Choi, M. Suh, Y. J. Kim, H. Song, Kyung-Hee Cho, H. W. Nah, S. U. Kwon, D. W. Kang, J. S. Kim

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives: To investigate the characteristics and prevalence of poststroke depression (PSD) and poststroke emotional incontinence (PSEI) and the factors related to these conditions at admission and 3 months after stroke. Methods: We evaluated 508 consecutive patients with acute ischemic stroke for PSD and PSEI at admission and 3 months later. PSD was evaluated using the Beck Depression Inventory, and PSEI was evaluated using Kim's criteria. Blood samples were collected and genotyped for the promoter region of the serotonin transporter protein (5-HTTLPR) and the number of tandem repeats within intron 2 (STin2 VNTR). Perceived social support (the ENRICHD Social Support Inventory) was also measured. Results: PSD and PSEI were present in 13.7% and 9.4% of patients, respectively, at admission and in 17.7% and 11.7%, respectively, at 3 months after stroke. Multivariate analyses showed that PSD at admission was associated with the NIH Stroke Scale score at admission (p < 0.001), whereas PSD at 3 months was associated with the presence of microbleeds (p < 0.01) and perceived low social support (p < 0.001). In contrast, only lesion location (p = 0.022) was associated with PSEI at admission, whereas modified Rankin Scale score (p = 0.019), STin2 VNTR (p = 0.040), and low social support (p = 0.042) were related to PSEI 3 months after stroke. Conclusions: Diverse factors such as neurologic dysfunction, lesion location, microbleeds, genetic traits, and social support are differently related to acute and subacute emotional disturbances. Strategies to prevent or manage these problems should consider these differences.

Original languageEnglish
Pages (from-to)1130-1137
Number of pages8
JournalNeurology
Volume78
Issue number15
DOIs
Publication statusPublished - 2012 Apr 10

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Depression
Social Support
Stroke
Equipment and Supplies
Serotonin Plasma Membrane Transport Proteins
Tandem Repeat Sequences
Affective Symptoms
Neurologic Manifestations
Genetic Promoter Regions
Introns
Multivariate Analysis
Proteins

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Choi-Kwon, S., Han, K., Choi, S., Suh, M., Kim, Y. J., Song, H., ... Kim, J. S. (2012). Poststroke depression and emotional incontinence: Factors related to acute and subacute stages. Neurology, 78(15), 1130-1137. https://doi.org/10.1212/WNL.0b013e31824f8090

Poststroke depression and emotional incontinence : Factors related to acute and subacute stages. / Choi-Kwon, S.; Han, K.; Choi, S.; Suh, M.; Kim, Y. J.; Song, H.; Cho, Kyung-Hee; Nah, H. W.; Kwon, S. U.; Kang, D. W.; Kim, J. S.

In: Neurology, Vol. 78, No. 15, 10.04.2012, p. 1130-1137.

Research output: Contribution to journalArticle

Choi-Kwon, S, Han, K, Choi, S, Suh, M, Kim, YJ, Song, H, Cho, K-H, Nah, HW, Kwon, SU, Kang, DW & Kim, JS 2012, 'Poststroke depression and emotional incontinence: Factors related to acute and subacute stages', Neurology, vol. 78, no. 15, pp. 1130-1137. https://doi.org/10.1212/WNL.0b013e31824f8090
Choi-Kwon, S. ; Han, K. ; Choi, S. ; Suh, M. ; Kim, Y. J. ; Song, H. ; Cho, Kyung-Hee ; Nah, H. W. ; Kwon, S. U. ; Kang, D. W. ; Kim, J. S. / Poststroke depression and emotional incontinence : Factors related to acute and subacute stages. In: Neurology. 2012 ; Vol. 78, No. 15. pp. 1130-1137.
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AU - Choi-Kwon, S.

AU - Han, K.

AU - Choi, S.

AU - Suh, M.

AU - Kim, Y. J.

AU - Song, H.

AU - Cho, Kyung-Hee

AU - Nah, H. W.

AU - Kwon, S. U.

AU - Kang, D. W.

AU - Kim, J. S.

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N2 - Objectives: To investigate the characteristics and prevalence of poststroke depression (PSD) and poststroke emotional incontinence (PSEI) and the factors related to these conditions at admission and 3 months after stroke. Methods: We evaluated 508 consecutive patients with acute ischemic stroke for PSD and PSEI at admission and 3 months later. PSD was evaluated using the Beck Depression Inventory, and PSEI was evaluated using Kim's criteria. Blood samples were collected and genotyped for the promoter region of the serotonin transporter protein (5-HTTLPR) and the number of tandem repeats within intron 2 (STin2 VNTR). Perceived social support (the ENRICHD Social Support Inventory) was also measured. Results: PSD and PSEI were present in 13.7% and 9.4% of patients, respectively, at admission and in 17.7% and 11.7%, respectively, at 3 months after stroke. Multivariate analyses showed that PSD at admission was associated with the NIH Stroke Scale score at admission (p < 0.001), whereas PSD at 3 months was associated with the presence of microbleeds (p < 0.01) and perceived low social support (p < 0.001). In contrast, only lesion location (p = 0.022) was associated with PSEI at admission, whereas modified Rankin Scale score (p = 0.019), STin2 VNTR (p = 0.040), and low social support (p = 0.042) were related to PSEI 3 months after stroke. Conclusions: Diverse factors such as neurologic dysfunction, lesion location, microbleeds, genetic traits, and social support are differently related to acute and subacute emotional disturbances. Strategies to prevent or manage these problems should consider these differences.

AB - Objectives: To investigate the characteristics and prevalence of poststroke depression (PSD) and poststroke emotional incontinence (PSEI) and the factors related to these conditions at admission and 3 months after stroke. Methods: We evaluated 508 consecutive patients with acute ischemic stroke for PSD and PSEI at admission and 3 months later. PSD was evaluated using the Beck Depression Inventory, and PSEI was evaluated using Kim's criteria. Blood samples were collected and genotyped for the promoter region of the serotonin transporter protein (5-HTTLPR) and the number of tandem repeats within intron 2 (STin2 VNTR). Perceived social support (the ENRICHD Social Support Inventory) was also measured. Results: PSD and PSEI were present in 13.7% and 9.4% of patients, respectively, at admission and in 17.7% and 11.7%, respectively, at 3 months after stroke. Multivariate analyses showed that PSD at admission was associated with the NIH Stroke Scale score at admission (p < 0.001), whereas PSD at 3 months was associated with the presence of microbleeds (p < 0.01) and perceived low social support (p < 0.001). In contrast, only lesion location (p = 0.022) was associated with PSEI at admission, whereas modified Rankin Scale score (p = 0.019), STin2 VNTR (p = 0.040), and low social support (p = 0.042) were related to PSEI 3 months after stroke. Conclusions: Diverse factors such as neurologic dysfunction, lesion location, microbleeds, genetic traits, and social support are differently related to acute and subacute emotional disturbances. Strategies to prevent or manage these problems should consider these differences.

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