Postural instability and cognitive dysfunction in early Parkinson's disease

Jong Moon Lee, Seong Beom Koh, Sungwon Chae, Woo Keun Seo, Do-Young Kwon, Ji Hyun Kim, Kyungmi Oh, Jong Sam Baik, Kun Woo Park

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Postural instability is one of the most disabling features of Parkinson's disease, usually occurring in late and advanced stages. The aim of this study was to investigate the postural performance of early-stage de novo Parkinson's disease patients with no clinical postural instability using computerized dynamic posturography. We sought to understand the relationship between postural sway and disease severity and the relationship between postural instability quantitatively measured by computerized dynamic posturography and cognitive impairment in early-stage Parkinson's disease patients. Method: Thirty-one subjects with Parkinson's disease and 20 healthy controls were assessed by the computerized dynamic posturography protocol using the sensory organization test and the motor control test. A neuropsychological assessment was also administered. Results: The mean equilibrium score for sensory organization test and the vestibular input ratio were significantly correlated with Hoehn-Yahr stage. No associations between motor latency for any motor control test condition and Hoehn-Yahr stage were found. The equilibrium score for sensory organization test correlated with the mini-mental status examination scores. There was a significant correlation between motor latency for large backward translation and mini-mental status examination scores. There were significant correlations between visual perception/construction/ memory of the neuropsychological battery test and the equilibrium score for sensory organization test and between verbal word learning test, controlled word association test and motor latency for large backward translation. Conclusion: These findings showed the postural instability present in early-stage (Hoehn-Yahr stage 2-2.5) Parkinson's disease. We also found a close relationship between postural instability and cognitive function in Parkinson's disease patients.

Original languageEnglish
Pages (from-to)473-482
Number of pages10
JournalCanadian Journal of Neurological Sciences
Volume39
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

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Parkinson Disease
Word Association Tests
Verbal Learning
Visual Perception
Neuropsychological Tests
Cognition
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Postural instability and cognitive dysfunction in early Parkinson's disease. / Lee, Jong Moon; Koh, Seong Beom; Chae, Sungwon; Seo, Woo Keun; Kwon, Do-Young; Kim, Ji Hyun; Oh, Kyungmi; Baik, Jong Sam; Park, Kun Woo.

In: Canadian Journal of Neurological Sciences, Vol. 39, No. 4, 01.07.2012, p. 473-482.

Research output: Contribution to journalArticle

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