Potential of human bone marrow stromal cells to accelerate wound healing in vitro

Seung Kyu Han, Tae Hwan Yoon, Dong Geun Lee, Min Ah Lee, Woo Kyung Kim

    Research output: Contribution to journalArticlepeer-review

    60 Citations (Scopus)

    Abstract

    The purpose of this pilot study was to compare proliferation, collagen synthesis, and growth factor production, which are important contributing factors for wound healing, of the bone marrow stromal cells (BSCs) with those of dermal fibroblasts in vitro. Cultured human BSCs and dermal fibroblasts from the same patients were seeded in 96-well culture plates. At 1, 3, and 5 days postincubating, cell proliferation, collagen synthesis, and secretion of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor β (TFG-β) were compared. We did not observe great differences in cell proliferation and TFG-β secretion. In contrast, the amount of collagen synthesis and the levels of the bFGF and the VEGF were much higher in the BSC group than the fibroblast group at each time interval (P < 0.05). Our results suggest that the BSCs may have superior potential to accelerate wound healing than the fibroblasts.

    Original languageEnglish
    Pages (from-to)414-419
    Number of pages6
    JournalAnnals of Plastic Surgery
    Volume55
    Issue number4
    DOIs
    Publication statusPublished - 2005 Oct

    Keywords

    • Bone marrow stromal cell
    • Wound healing

    ASJC Scopus subject areas

    • Surgery

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