Potential of human bone marrow stromal cells to accelerate wound healing in vitro

Seung-Kyu Han, Tae Hwan Yoon, Dong Geun Lee, Min Ah Lee, Woo-Kyung Kim

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58 Citations (Scopus)

Abstract

The purpose of this pilot study was to compare proliferation, collagen synthesis, and growth factor production, which are important contributing factors for wound healing, of the bone marrow stromal cells (BSCs) with those of dermal fibroblasts in vitro. Cultured human BSCs and dermal fibroblasts from the same patients were seeded in 96-well culture plates. At 1, 3, and 5 days postincubating, cell proliferation, collagen synthesis, and secretion of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor β (TFG-β) were compared. We did not observe great differences in cell proliferation and TFG-β secretion. In contrast, the amount of collagen synthesis and the levels of the bFGF and the VEGF were much higher in the BSC group than the fibroblast group at each time interval (P < 0.05). Our results suggest that the BSCs may have superior potential to accelerate wound healing than the fibroblasts.

Original languageEnglish
Pages (from-to)414-419
Number of pages6
JournalAnnals of Plastic Surgery
Volume55
Issue number4
DOIs
Publication statusPublished - 2005 Oct 1

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Keywords

  • Bone marrow stromal cell
  • Wound healing

ASJC Scopus subject areas

  • Surgery

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