Potential prognostic factor in alternating electric fields therapy based on absorbed energy in tissue

Geon Oh, Yunhui Jo, Yongha Gi, Heehun Sung, Jaehyun Seo, Hyunwoo Kim, Jaemin Lee, Myonggeun Yoon

Research output: Contribution to journalArticlepeer-review

Abstract

The present study aimed to determine a method for estimating a potential prognostic factor in alternating electric fields for the treatment of solid tumors based on cell survival curves that evaluate cell proliferation capability. In AGS, B16F10, U373, and HPAF-II cancer cell lines, the proportional relationships of the electric field magnitude and the duration of application with the proliferation of cancer cell lines was identified by in vitro alternating current electric field experiments performed under various conditions. A prognostic factor applicable to alternating electric field therapy was developed by identifying proportional relationships of the electric field magnitude and the duration of application with the proliferation of the four cancer cell lines. Through the experimental results, the absorbed energy in tissue has been suggested as a potential prognostic factor in alternating electric field therapy. The absorbed energy in tissue can be used as a reference to quantify the inhibition of cell proliferation related to control, enabling systematic assessment of alternating electric field therapy which, to date, has not been possible.

Original languageEnglish
Article number095311
JournalAIP Advances
Volume12
Issue number9
DOIs
Publication statusPublished - 2022 Sep 1

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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