Potential use of blood bank platelet concentrates to accelerate wound healing of diabetic ulcers

Seung Kyu Han, Deok Woo Kim, Seong Ho Jeong, Yong Taek Hong, Hong Suh Woo, Woo Kyung Kim, Finn Gottrup

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Many clinical trials have shown the effectiveness of platelet releasate on diabetic wound healing, but large volumes of blood must be aspirated from patients and a platelet separator is required. This study was undertaken to investigate the potential of blood bank platelet concentrate (BBPC) for accelerating diabetic wound healing. Platelet-derived growth factor-BB (PDGF-BB) contents in BBPC were determined by enzyme-linked immunosorbent assay in vitro, and the in vivo study involved comparing extents of wound healing in BBPC-treated and control groups using diabetic mouse wound models. In the in vitro study, 5.2 ± 1.2 pg of PDGF-BB was found to be released by 1 million platelets in fresh BBPC, and adding thrombin to BBPC significantly increased the levels of PDGF-BB released. Our in vivo study in diabetic mice revealed that BBPC treatment greatly accelerated wound healing. Our results suggest that BBPC has potential to accelerate the healing of diabetic ulcers.

    Original languageEnglish
    Pages (from-to)532-537
    Number of pages6
    JournalAnnals of Plastic Surgery
    Volume59
    Issue number5
    DOIs
    Publication statusPublished - 2007 Nov

    Keywords

    • Blood bank platelet concentrate
    • Diabetic ulcer
    • Wound healing

    ASJC Scopus subject areas

    • Surgery

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