PPARγ pro12Ala and his447His polymorphisms and susceptibility to alzheimer’s disease: A meta-analysis

Young Ho Lee, Gwan Gyu Song

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. A total of eight studies were considered in our meta-analysis, comprising 2948 patients with AD and 3753 controls. Meta-analysis showed no association between AD and the PPARg Pro12Ala G allele in any of the study subjects [odds ratio (OR) = 1.013, 95% confidence interval (95%CI) = 0.906-1.132, P = 0.821] or in the European and Asian populations (OR = 0.997, 95%CI = 0.890-1.118, P = 0.965; OR = 1.409, 95%CI = 0.832-2.387, P = 0.202, respectively). We tested whether the APOE ɛ4 allele affects the association between the PPARγ Pro12Ala polymorphism and AD. Meta-analysis showed no association between AD and the PPARγ G allele in any of the study subjects with or without the APOE ɛ4 allele. Meta-analysis showed no association between AD and the PPARg His447His T allele in the European population (OR for T allele = 0.912, 95%CI = 0.732-1.136, P = 0.409). This meta-analysis has shown that there is a lack of association between the PPARγ Pro12Ala and His447His polymorphisms and AD risk.

Original languageEnglish
Article numberA448
Pages (from-to)7248-7257
Number of pages10
JournalGenetics and Molecular Research
Volume14
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E
  • Meta-analysis
  • Polymorphism
  • PPARγ

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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