Practice patterns of urologists in managing korean men aged 40 years or younger with high serum prostate-specific antigen levels

Dae Seon Yoo, Seung Hyo Woo, Seok Cho, Seok Ho Kang, Sang Jin Kim, Sung Yul Park, Sang Hyub Lee, Seung Hyun Jeon, Jinsung Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To investigate the practice patterns of urologists in managing Korean men aged 40 years or younger with high serum prostate-specific antigen (PSA). Materials and Methods Data were collected from general health screenings conducted at 4 university hospitals between 2004 and 2012. Eligibility criteria were Korean men aged ≤40 years who were seen by urologists for high PSA (>2.5 ng/mL). After excluding individuals with chronic prostatitis and any infectious symptoms and/or signs, the practice patterns of urologists managing 237 eligible men were analyzed. Results The most common practice was observation after antibiotics (40.5%), followed by reassurance (38.4%), prostate biopsy (PBx) after antibiotics (11.8%), PBx after PSA follow-up (7.6%), and immediate PBx (1.7%). Antibiotics were prescribed empirically to 124 patients (52.3%). Of the entire patients, 145 of 237 (61.2%) had at least 1 follow-up PSA, and the follow-up PSA with median interval of 43 days (interquartile range, 26-149) was higher than initial PSA in 66 of 145 (45.5%). Of the 98 patients undergoing follow-up PSA after initial antibiotic treatment, 53 (54.1%) experienced a decline in PSA, whereas 45 (45.9%) experienced a rise in PSA. PBx was performed in 50 of 237 (21.1%), and only a single case (2%) of prostate cancer was diagnosed. Conclusion In managing men ≤40 years with high PSA, the most common practice pattern was observation after antibiotic treatment despite lack of evidences. Furthermore, 1 in 5 urologists performed PBx to rule out cancer. Given the very low prevalence of cancer in this age group, clear guidelines are needed for appropriate management and consistency of care.

Original languageEnglish
Pages (from-to)1339-1343
Number of pages5
JournalUrology
Volume83
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Prostate-Specific Antigen
Serum
Anti-Bacterial Agents
Observation
Urologists
Prostatitis
Signs and Symptoms
Prostate
Neoplasms
Prostatic Neoplasms
Age Groups
Guidelines
Biopsy
Health
Therapeutics

ASJC Scopus subject areas

  • Urology

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Practice patterns of urologists in managing korean men aged 40 years or younger with high serum prostate-specific antigen levels. / Yoo, Dae Seon; Woo, Seung Hyo; Cho, Seok; Kang, Seok Ho; Kim, Sang Jin; Park, Sung Yul; Lee, Sang Hyub; Jeon, Seung Hyun; Park, Jinsung.

In: Urology, Vol. 83, No. 6, 01.01.2014, p. 1339-1343.

Research output: Contribution to journalArticle

Yoo, Dae Seon ; Woo, Seung Hyo ; Cho, Seok ; Kang, Seok Ho ; Kim, Sang Jin ; Park, Sung Yul ; Lee, Sang Hyub ; Jeon, Seung Hyun ; Park, Jinsung. / Practice patterns of urologists in managing korean men aged 40 years or younger with high serum prostate-specific antigen levels. In: Urology. 2014 ; Vol. 83, No. 6. pp. 1339-1343.
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abstract = "Objective To investigate the practice patterns of urologists in managing Korean men aged 40 years or younger with high serum prostate-specific antigen (PSA). Materials and Methods Data were collected from general health screenings conducted at 4 university hospitals between 2004 and 2012. Eligibility criteria were Korean men aged ≤40 years who were seen by urologists for high PSA (>2.5 ng/mL). After excluding individuals with chronic prostatitis and any infectious symptoms and/or signs, the practice patterns of urologists managing 237 eligible men were analyzed. Results The most common practice was observation after antibiotics (40.5{\%}), followed by reassurance (38.4{\%}), prostate biopsy (PBx) after antibiotics (11.8{\%}), PBx after PSA follow-up (7.6{\%}), and immediate PBx (1.7{\%}). Antibiotics were prescribed empirically to 124 patients (52.3{\%}). Of the entire patients, 145 of 237 (61.2{\%}) had at least 1 follow-up PSA, and the follow-up PSA with median interval of 43 days (interquartile range, 26-149) was higher than initial PSA in 66 of 145 (45.5{\%}). Of the 98 patients undergoing follow-up PSA after initial antibiotic treatment, 53 (54.1{\%}) experienced a decline in PSA, whereas 45 (45.9{\%}) experienced a rise in PSA. PBx was performed in 50 of 237 (21.1{\%}), and only a single case (2{\%}) of prostate cancer was diagnosed. Conclusion In managing men ≤40 years with high PSA, the most common practice pattern was observation after antibiotic treatment despite lack of evidences. Furthermore, 1 in 5 urologists performed PBx to rule out cancer. Given the very low prevalence of cancer in this age group, clear guidelines are needed for appropriate management and consistency of care.",
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AU - Yoo, Dae Seon

AU - Woo, Seung Hyo

AU - Cho, Seok

AU - Kang, Seok Ho

AU - Kim, Sang Jin

AU - Park, Sung Yul

AU - Lee, Sang Hyub

AU - Jeon, Seung Hyun

AU - Park, Jinsung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective To investigate the practice patterns of urologists in managing Korean men aged 40 years or younger with high serum prostate-specific antigen (PSA). Materials and Methods Data were collected from general health screenings conducted at 4 university hospitals between 2004 and 2012. Eligibility criteria were Korean men aged ≤40 years who were seen by urologists for high PSA (>2.5 ng/mL). After excluding individuals with chronic prostatitis and any infectious symptoms and/or signs, the practice patterns of urologists managing 237 eligible men were analyzed. Results The most common practice was observation after antibiotics (40.5%), followed by reassurance (38.4%), prostate biopsy (PBx) after antibiotics (11.8%), PBx after PSA follow-up (7.6%), and immediate PBx (1.7%). Antibiotics were prescribed empirically to 124 patients (52.3%). Of the entire patients, 145 of 237 (61.2%) had at least 1 follow-up PSA, and the follow-up PSA with median interval of 43 days (interquartile range, 26-149) was higher than initial PSA in 66 of 145 (45.5%). Of the 98 patients undergoing follow-up PSA after initial antibiotic treatment, 53 (54.1%) experienced a decline in PSA, whereas 45 (45.9%) experienced a rise in PSA. PBx was performed in 50 of 237 (21.1%), and only a single case (2%) of prostate cancer was diagnosed. Conclusion In managing men ≤40 years with high PSA, the most common practice pattern was observation after antibiotic treatment despite lack of evidences. Furthermore, 1 in 5 urologists performed PBx to rule out cancer. Given the very low prevalence of cancer in this age group, clear guidelines are needed for appropriate management and consistency of care.

AB - Objective To investigate the practice patterns of urologists in managing Korean men aged 40 years or younger with high serum prostate-specific antigen (PSA). Materials and Methods Data were collected from general health screenings conducted at 4 university hospitals between 2004 and 2012. Eligibility criteria were Korean men aged ≤40 years who were seen by urologists for high PSA (>2.5 ng/mL). After excluding individuals with chronic prostatitis and any infectious symptoms and/or signs, the practice patterns of urologists managing 237 eligible men were analyzed. Results The most common practice was observation after antibiotics (40.5%), followed by reassurance (38.4%), prostate biopsy (PBx) after antibiotics (11.8%), PBx after PSA follow-up (7.6%), and immediate PBx (1.7%). Antibiotics were prescribed empirically to 124 patients (52.3%). Of the entire patients, 145 of 237 (61.2%) had at least 1 follow-up PSA, and the follow-up PSA with median interval of 43 days (interquartile range, 26-149) was higher than initial PSA in 66 of 145 (45.5%). Of the 98 patients undergoing follow-up PSA after initial antibiotic treatment, 53 (54.1%) experienced a decline in PSA, whereas 45 (45.9%) experienced a rise in PSA. PBx was performed in 50 of 237 (21.1%), and only a single case (2%) of prostate cancer was diagnosed. Conclusion In managing men ≤40 years with high PSA, the most common practice pattern was observation after antibiotic treatment despite lack of evidences. Furthermore, 1 in 5 urologists performed PBx to rule out cancer. Given the very low prevalence of cancer in this age group, clear guidelines are needed for appropriate management and consistency of care.

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