@article{d676e768985a42f9abb8d672d9c04141,
title = "Prdm4 induction by the small molecule butein promotes white adipose tissue browning",
abstract = "Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.",
author = "Song, {No Joon} and Seri Choi and Prashant Rajbhandari and Chang, {Seo Hyuk} and Suji Kim and Laurent Vergnes and Kwon, {So Mi} and Yoon, {Jung Hoon} and Sukchan Lee and Ku, {Jin Mo} and Lee, {Jeong Soo} and Karen Reue and Koo, {Seung Hoi} and Peter Tontonoz and Park, {Kye Won}",
note = "Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.). Publisher Copyright: {\textcopyright} 2016 Nature America, Inc. All rights reserved.",
year = "2016",
month = jul,
day = "1",
doi = "10.1038/nchembio.2081",
language = "English",
volume = "12",
pages = "479--481",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "7",
}
