Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song, Seri Choi, Prashant Rajbhandari, Seo Hyuk Chang, Suji Kim, Laurent Vergnes, So Mi Kwon, Jung Hoon Yoon, Sukchan Lee, Jin Mo Ku, Jeong Soo Lee, Karen Reue, Seung Hoi Koo, Peter Tontonoz, Kye Won Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalNature Chemical Biology
Volume12
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Song, N. J., Choi, S., Rajbhandari, P., Chang, S. H., Kim, S., Vergnes, L., Kwon, S. M., Yoon, J. H., Lee, S., Ku, J. M., Lee, J. S., Reue, K., Koo, S. H., Tontonoz, P., & Park, K. W. (2016). Prdm4 induction by the small molecule butein promotes white adipose tissue browning. Nature Chemical Biology, 12(7), 479-481. https://doi.org/10.1038/nchembio.2081