Abstract
BACKGROUND: The infant Jarvik 2000 heart is a very small, hermetically sealed, intracorporeal, axial-flow ventricular assist device (VAD) designed for circulatory support in neonates and infants. The anatomic fit, short-term biocompatibility and hemodynamic performance of the device were evaluated in a neonate piglet model. METHODS: The infant Jarvik 2000 heart with two different blade profiles (low- or high-flow blade design) was tested in 6 piglets (8.8±0.9 kg). Using a median sternotomy, the pump was placed in the left ventricle through the apex without cardiopulmonary bypass. An outflow graft was anastomosed to the ascending aorta. Hemodynamics and biocompatibility were studied for 6 hours. RESULTS: All 6 pumps were implanted without complication. Optimal anatomic positioning was found with the pump body inserted 2.4 cm into the left ventricle. Hemodynamics demonstrated stability throughout the 6-hour duration. The pump flow increased from 0.27 to 0.95 liter/min at increasing speeds from 18 to 31 krpm for the low-flow blade design, whereas the pump flow increased from 0.54 liter/min to 1.12 liters/min at increasing speeds from 16 krpm to 31 krpm for the high-flow blade design. At higher speeds, >80% of flow could be supplied by the device. Blood chemistry and final pathology demonstrated no acute organ injury or thrombosis for either blade design. CONCLUSIONS: The infant Jarvik 2000 heart is anatomically and biologically compatible with an short-term neonate piglet model. This in vivo study demonstrates the future feasibility of this device for clinical use.
| Original language | English |
|---|---|
| Pages (from-to) | 112-119 |
| Number of pages | 8 |
| Journal | Journal of Heart and Lung Transplantation |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 Jan 1 |
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Keywords
- biocompatibility
- hemodynamics
- mechanical circulatory support
- pediatric patients
- ventricular assist device
ASJC Scopus subject areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine
- Transplantation
Cite this
Pre-clinical evaluation of the infant Jarvik 2000 heart in a neonate piglet model. / Wei, Xufeng; Li, Tieluo; Li, Shuying; Son, Ho Sung; Sanchez, Pablo; Niu, Shuqiong; Claire Watkins, A.; Defilippi, Christopher; Jarvik, Robert; Wu, Zhongjun J.; Griffith, Bartley P.
In: Journal of Heart and Lung Transplantation, Vol. 32, No. 1, 01.01.2013, p. 112-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pre-clinical evaluation of the infant Jarvik 2000 heart in a neonate piglet model
AU - Wei, Xufeng
AU - Li, Tieluo
AU - Li, Shuying
AU - Son, Ho Sung
AU - Sanchez, Pablo
AU - Niu, Shuqiong
AU - Claire Watkins, A.
AU - Defilippi, Christopher
AU - Jarvik, Robert
AU - Wu, Zhongjun J.
AU - Griffith, Bartley P.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: The infant Jarvik 2000 heart is a very small, hermetically sealed, intracorporeal, axial-flow ventricular assist device (VAD) designed for circulatory support in neonates and infants. The anatomic fit, short-term biocompatibility and hemodynamic performance of the device were evaluated in a neonate piglet model. METHODS: The infant Jarvik 2000 heart with two different blade profiles (low- or high-flow blade design) was tested in 6 piglets (8.8±0.9 kg). Using a median sternotomy, the pump was placed in the left ventricle through the apex without cardiopulmonary bypass. An outflow graft was anastomosed to the ascending aorta. Hemodynamics and biocompatibility were studied for 6 hours. RESULTS: All 6 pumps were implanted without complication. Optimal anatomic positioning was found with the pump body inserted 2.4 cm into the left ventricle. Hemodynamics demonstrated stability throughout the 6-hour duration. The pump flow increased from 0.27 to 0.95 liter/min at increasing speeds from 18 to 31 krpm for the low-flow blade design, whereas the pump flow increased from 0.54 liter/min to 1.12 liters/min at increasing speeds from 16 krpm to 31 krpm for the high-flow blade design. At higher speeds, >80% of flow could be supplied by the device. Blood chemistry and final pathology demonstrated no acute organ injury or thrombosis for either blade design. CONCLUSIONS: The infant Jarvik 2000 heart is anatomically and biologically compatible with an short-term neonate piglet model. This in vivo study demonstrates the future feasibility of this device for clinical use.
AB - BACKGROUND: The infant Jarvik 2000 heart is a very small, hermetically sealed, intracorporeal, axial-flow ventricular assist device (VAD) designed for circulatory support in neonates and infants. The anatomic fit, short-term biocompatibility and hemodynamic performance of the device were evaluated in a neonate piglet model. METHODS: The infant Jarvik 2000 heart with two different blade profiles (low- or high-flow blade design) was tested in 6 piglets (8.8±0.9 kg). Using a median sternotomy, the pump was placed in the left ventricle through the apex without cardiopulmonary bypass. An outflow graft was anastomosed to the ascending aorta. Hemodynamics and biocompatibility were studied for 6 hours. RESULTS: All 6 pumps were implanted without complication. Optimal anatomic positioning was found with the pump body inserted 2.4 cm into the left ventricle. Hemodynamics demonstrated stability throughout the 6-hour duration. The pump flow increased from 0.27 to 0.95 liter/min at increasing speeds from 18 to 31 krpm for the low-flow blade design, whereas the pump flow increased from 0.54 liter/min to 1.12 liters/min at increasing speeds from 16 krpm to 31 krpm for the high-flow blade design. At higher speeds, >80% of flow could be supplied by the device. Blood chemistry and final pathology demonstrated no acute organ injury or thrombosis for either blade design. CONCLUSIONS: The infant Jarvik 2000 heart is anatomically and biologically compatible with an short-term neonate piglet model. This in vivo study demonstrates the future feasibility of this device for clinical use.
KW - biocompatibility
KW - hemodynamics
KW - mechanical circulatory support
KW - pediatric patients
KW - ventricular assist device
UR - http://www.scopus.com/inward/record.url?scp=84871382838&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871382838&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2012.10.011
DO - 10.1016/j.healun.2012.10.011
M3 - Article
C2 - 23260711
AN - SCOPUS:84871382838
VL - 32
SP - 112
EP - 119
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
SN - 1053-2498
IS - 1
ER -