Pre-clinical mouse models of human prostate cancer and their utility in drug discovery.

Serk In Park, Sun Jin Kim, Laurie K. McCauley, Gary E. Gallick

Research output: Contribution to journalArticle

Abstract

In vivo animal experiments are essential to current prostate cancer research, and are particularly critical to studying interactions between tumor cells and their microenvironment. Numerous pre-clinical animal models of prostate cancer are currently available, including transgenic mouse models and human prostate cancer xenograft mouse models. In contrast to transgenic mouse models producing more heterogeneous cohorts of tumors, xenograft mouse models provide more controlled approaches. This unit describes the detailed procedures necessary to establish several distinct pre-clinical mouse models of human prostate cancer, including an orthotopic prostate xenograft model, an orthotopic bone metastasis model, an experimental metastasis model of intra-cardiac injection, and a vossicle model of tumor-bone interaction.

Original languageEnglish
JournalCurrent protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]
VolumeChapter 14
Publication statusPublished - 2010 Dec 1
Externally publishedYes

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Drug Discovery
Prostatic Neoplasms
Heterografts
Transgenic Mice
Neoplasm Metastasis
Cellular Microenvironment
Bone and Bones
Neoplasms
Prostate
Theoretical Models
Animal Models
Injections
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pre-clinical mouse models of human prostate cancer and their utility in drug discovery. / Park, Serk In; Kim, Sun Jin; McCauley, Laurie K.; Gallick, Gary E.

In: Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.], Vol. Chapter 14, 01.12.2010.

Research output: Contribution to journalArticle

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