Predicting how cells spread and migrate: Focal adhesion size does matter

Dong Hwee Kim, Denis Wirtz

Research output: Contribution to journalComment/debate

30 Citations (Scopus)

Abstract

Efficient cell migration is central to the normal development of tissues and organs and is involved in a wide range of human diseases, including cancer metastasis, immune responses, and cardiovascular disorders. Mesenchymal migration is modulated by focal-adhesion proteins, which organize into large integrin-rich protein complexes at the basal surface of adherent cells. Whether the extent of clustering of focal-adhesion proteins is actually required for effective migration is unclear. We recently demonstrated that the depletion of major focal-adhesion proteins, as well as modulation of matrix compliance, actin assembly, mitochondrial activity, and DNA recombination, all converged into highly predictable, inter-related, biphasic changes in focal adhesion size and cell migration. Herein, we further discuss the role of focal adhesions in controlling cell spreading and test their potential role in cell migration.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalCell Adhesion and Migration
Volume7
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Cell migration
  • Focal adhesions
  • High-throughput phenotyping
  • Mechanosensing
  • Systems biology

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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